Hotels in Downtown South San Francisco

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Tonight
Dec 10 - Dec 11
Tomorrow
Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Where to stay in Downtown South San Francisco?

Exterior
La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2009)
The price is CNY715
CNY840 total
includes taxes & fees
Jan 1 - Jan 2, 2026
La Quinta Inn & Suites by Wyndham San Francisco Airport N
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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When is the best time to visit Downtown South San Francisco?

Our prices for hotels in Downtown South San Francisco are cheapest in March
Price trends for hotels in Downtown South San Francisco
Pricing is based on two traveler single night rates
View properties in December
Currently viewing crowd sizes and weather for December.
Typical weather for South San Francisco
December
Low crowds
High 14°C / low 9°C. Sunny most days.
View properties in December
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December, Low crowds, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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14°
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January, Low crowds, average high temperature 14 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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15°
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February, Low crowds, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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15°
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March, Moderate crowds, average high temperature 15 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
16°
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April, Moderate crowds, average high temperature 16 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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17°
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May, High crowds, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
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19°
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June, Moderate crowds, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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19°
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July, High crowds, average high temperature 19 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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20°
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August, High crowds, average high temperature 20 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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20°
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September, High crowds, average high temperature 20 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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19°
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October, Moderate crowds, average high temperature 19 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
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17°
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November, Low crowds, average high temperature 17 degrees Celsius, average low temperature 11 degrees Celsius. Sunny most days.
11°
Monthly weather averages (˚C)

Check out reviews of Downtown South San Francisco hotels guests love

Handlery Union Square Hotel

Handlery Union Square Hotel

10/10 Excellent
"All of it was great! We will definitely stay again. "
Courtney 1-night trip
Posted 11 hours ago
Handlery Union Square Hotel

Frequently asked questions

Is Downtown South San Francisco expensive to stay in?
You can find great hotels from CNY634 in Downtown South San Francisco to suit a range of budgets. If you're looking for an affordable stay in Downtown South San Francisco, La Quinta Inn & Suites by Wyndham San Francisco Airport N is a great low-cost option. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for Downtown South San Francisco hotels?
Discover great deals on hotels in Downtown South San Francisco with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Downtown South San Francisco hotels.
Can I receive a refund if I cancel my Downtown South San Francisco hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some Downtown South San Francisco hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in Downtown South San Francisco?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In Downtown South San Francisco, our travelers love:
What are some of the best family hotels in Downtown South San Francisco?
If you're vacationing with your family, La Quinta Inn & Suites by Wyndham San Francisco Airport N is one of the best family hotels in Downtown South San Francisco. La Quinta Inn & Suites by Wyndham San Francisco Airport N has a great average guest score of 8 out of 10 and amenities like an outdoor pool, a free continental breakfast and in-room cribs. To explore more family hotels in Downtown South San Francisco, use the "Family friendly" filter in your search on Hotels.com.
What are some of the best Downtown South San Francisco hotels with a pool?
Book a Downtown South San Francisco hotel with a pool for some added relaxation or exercise on your trip. La Quinta Inn & Suites by Wyndham San Francisco Airport N is a top-rated hotel with an outdoor pool, and an average guest score of 8 out of 10. This hotel also features a free continental breakfast and a 24-hour gym. For more Downtown South San Francisco hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
Is it worth staying in Downtown South San Francisco?
There are 13 hotels in the area to find your perfect somewhere. Basing yourself in Downtown South San Francisco makes it easy to explore South San Francisco, including the neighborhoods of Excelsior and Bayview.
Find out more about Downtown South San Francisco

What's Downtown South San Francisco Like?

If you want to find the perfect part of the city to explore, why not check out Downtown South San Francisco? Top places in the larger area to visit include Chase Center and Oracle Park. Moscone Convention Center is one not-to-miss sight nearby.

How to Get to Downtown South San Francisco

Flying to:

  • San Francisco Intl. Airport (SFO), 3.2 mi (5.2 km) from Downtown South San Francisco
  • Oakland Intl. Airport (OAK), 11.8 mi (18.9 km) from Downtown South San Francisco
  • San Carlos, CA (SQL), 13.4 mi (21.5 km) from Downtown South San Francisco

Things to See and Do in and around Downtown South San Francisco

Things to See near Downtown South San Francisco:

  • South San Francisco Convention Center (0.9 mi/1.5 km away)
  • San Francisco Baking Institute (1.6 mi/2.6 km away)
  • Cow Palace (3.5 mi/5.6 km away)
  • Bayfront Park (4.2 mi/6.8 km away)
  • San Bruno Point Park (1.7 mi/2.7 km away)

Things to Do near Downtown South San Francisco:

  • SFO Museum (1.7 mi/2.8 km away)
  • Artichoke Joe's Casino (2 mi/3.2 km away)
  • Serramonte Center (3.2 mi/5.1 km away)
  • Millbrae Square Shopping Center (3.8 mi/6.1 km away)
  • See's Candies (1 mi/1.7 km away)

When Is the Best Time to Visit South San Francisco?

  • Hottest months: September, August, October, July (average 62°F)
  • Coldest months: February, January, December, March (average 53°F)
  • Rainiest months: December, January, February, March (average 4 inches of rainfall)

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