Hotels in Medical Center District

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Where to stay in Medical Center District?

Lobby
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
2.5 star property
Medical Center District
9.0 out of 10, Wonderful, (1004)
The price is CNY584
CNY682 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See more propertiesforward arrow

When is the best time to visit Medical Center District?

Our prices for hotels in Medical Center District are cheapest in January
Price trends for hotels in Medical Center District
Pricing is based on two traveler single night rates
View properties in December
Currently viewing crowd sizes and weather for December.
Typical weather for San Antonio
December
High crowds
High 18°C / low 9°C. Sunny most days.
View properties in December
18°
weather_sun
December, High crowds, average high temperature 18 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
17°
weather_sun
January, Low crowds, average high temperature 17 degrees Celsius, average low temperature 7 degrees Celsius. Sunny most days.
7°
19°
weather_sun
February, Low crowds, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
24°
weather_sun
March, High crowds, average high temperature 24 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
13°
27°
weather_sun
April, Moderate crowds, average high temperature 27 degrees Celsius, average low temperature 16 degrees Celsius. Sunny most days.
16°
30°
weather_sun
May, Moderate crowds, average high temperature 30 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
34°
weather_sun
June, Moderate crowds, average high temperature 34 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
36°
weather_sun
July, High crowds, average high temperature 36 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
36°
weather_sun
August, Moderate crowds, average high temperature 36 degrees Celsius, average low temperature 25 degrees Celsius. Sunny most days.
25°
33°
weather_sun
September, Low crowds, average high temperature 33 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
28°
weather_sun
October, High crowds, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
18°
22°
weather_sun
November, Low crowds, average high temperature 22 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
12°
Monthly weather averages (˚C)

Top landmarks in Medical Center District

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is worth a pic or two when discovering Medical Center District. Why not take a stroll along the riverfront and watch the sunset while you're here?
See properties

Cinemark San Antonio 16

Medical Center District is home to Cinemark San Antonio 16, so why not stop by during your stay in San Antonio.
See properties

Check out reviews of Medical Center District hotels guests love

Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

10/10 Excellent
"The hotel was beautiful. The room, though slightly outdated, was comfortable and spacious. Though I will say, the city view I paid for was disappointing as my window just faced th courtyard. Other than that my stay was wonderful. "
Michael 3-night trip
Posted 5 hours ago
Hotel Valencia Riverwalk

Frequently asked questions

Is Medical Center District expensive to stay in?
You can find great hotels from CNY344 in Medical Center District to suit a range of budgets. If you're looking for an affordable stay in Medical Center District, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW and Clarion Pointe near Medical Center are some great low-cost options. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for Medical Center District hotels?
Discover great deals on hotels in Medical Center District with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Medical Center District hotels.
Can I receive a refund if I cancel my Medical Center District hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some Medical Center District hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in Medical Center District?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In Medical Center District, our travelers love:
What are some of the best Medical Center District hotels for couples?
One of the best Medical Center District hotels for couples is San Antonio Marriott Northwest Medical Center. San Antonio Marriott Northwest Medical Center is a popular hotel with a restaurant, as well as champagne service in each guestroom. Travelers also love La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW where you can enjoy an outdoor pool. Find more romantic Medical Center District hotels by using the "Traveler experience" filter in your search and selecting "Adults only" or "Romantic".
What are some of the best family hotels in Medical Center District?
If you're vacationing with your family, Courtyard by Marriott Medical Center San Antonio and San Antonio Marriott Northwest Medical Center are some of the best family hotels in Medical Center District. Courtyard by Marriott Medical Center San Antonio has a great average guest score of 8.8 out of 10 and amenities like an outdoor pool, children's meals and in-room cribs. Kids are welcome at San Antonio Marriott Northwest Medical Center, too. Travelers leave glowing reviews of this hotel, which has an outdoor pool, children's meals, in-room cribs, and more. To explore more family hotels in Medical Center District, use the "Family friendly" filter in your search on Hotels.com.
What are some of the best Medical Center District hotels with a pool?
Book a Medical Center District hotel with a pool for some added relaxation or exercise on your trip. Drury Inn & Suites San Antonio Northwest Medical Center is a top-rated hotel with an indoor pool, and an average guest score of 9.2 out of 10. This hotel also features a hot tub and a free buffet breakfast. Courtyard by Marriott Medical Center San Antonio is another great hotel that features an outdoor pool, along with a restaurant and a bar/lounge. For more Medical Center District hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
What are some of the top Medical Center District hotels with free parking?
If you're traveling by car, make your life easier by booking a Medical Center District hotel with free parking. Our travelers like:
Is it worth staying in Medical Center District?
You're spoilt for choice with 121 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in Medical Center District makes it easy to explore San Antonio, including the neighborhoods of Uptown and Far West Side.
What are some great hotels in Medical Center District with balconies?
There are some top hotels in Medical Center District that offer rooms with a balcony. Check out San Antonio Marriott Northwest Medical Center which has a high guest score of 8.6 out of 10, and balconies in some rooms. Another popular choice is Courtyard by Marriott Medical Center San Antonio, which offers balconies in some rooms and has a great guest score of 8.8.
Find out more about Medical Center District

Keep exploring