Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Get last-minute hotel deals in Southeast Missouri and save more
Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.
Check out reviews of Southeast Missouri hotels guests love
Frequently asked questions
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
