Photo by Henry Fitzthum
Hotels in Southeast Missouri
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Where to stay in Southeast Missouri?

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
cleanliness Explore the stunning forest views with free breakfast, indoor pool, and dining options.
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,003 reviews)
cleanliness Peaceful highway-adjacent retreat with indoor and outdoor pool options.
The price is CNY655
CNY753 total
includes taxes & fees
Jan 22 - Jan 23

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (472 reviews)
cleanliness Serene and well-maintained riverfront property with gaming excitement and quiet comfort.
The price is CNY530
CNY602 total
includes taxes & fees
Jan 30 - Jan 31

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
7.8 out of 10, Good, (1,000 reviews)
cleanliness Experience clean comfort near North Main Street Historic District and art museum.
The price is CNY397
CNY419 total
includes taxes & fees
Jan 20 - Jan 21

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (979 reviews)
cleanliness Relax in dual indoor-outdoor pool options in this Poplar Bluff tranquil retreat.
The price is CNY725
CNY819 total
includes taxes & fees
Feb 6 - Feb 7

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very Good, (730 reviews)
cleanliness Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.
The price is CNY387
CNY441 total
includes taxes & fees
Jan 21 - Jan 22

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (151 reviews)
cleanliness Stay near Fort D Historic Site with a free breakfast and indoor pool.
The price is CNY613
CNY692 total
includes taxes & fees
Jan 25 - Jan 26

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (688 reviews)
The price is CNY557
CNY603 total
includes taxes & fees
Jan 25 - Jan 26

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
cleanliness Restful hotel near Cape Splash with indoor pool and complimentary amenities.
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22

Best Western Plus Sikeston
Best Western Plus SikestonSikeston
8.4 out of 10, Very Good, (1,003 reviews)
cleanliness Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.
The price is CNY498
CNY567 total
includes taxes & fees
Jan 25 - Jan 26

Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical CenterCape Girardeau
9.0 out of 10, Wonderful, (1,003 reviews)
cleanliness Perfect location near medical center with helpful staff and peaceful atmosphere.
The price is CNY739
CNY833 total
includes taxes & fees
Jan 18 - Jan 19

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,002 reviews)
cleanliness Quiet escape near Cape Girardeau with an indoor pool for year-round enjoyment.
The price is CNY578
CNY611 total
includes taxes & fees
Jan 19 - Jan 20

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (578 reviews)
cleanliness Lakeside haven with championship golf and warm service at this serene retreat.
The price is CNY899
CNY1,023 total
includes taxes & fees
Jan 20 - Jan 21

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (219 reviews)
cleanliness Explore nature's playground in Missouri's scenic Eminence wilderness.
The price is CNY1,143
CNY1,208 total
includes taxes & fees
Jan 19 - Jan 20

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (798 reviews)
cleanliness Experience a comfortable stay minutes from North Main Street Historic District.
The price is CNY755
CNY845 total
includes taxes & fees
Feb 14 - Feb 15

EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (84 reviews)
cleanliness Rustic hotel with hiking trails and free perks in the charming town of Marble Hill.

Hampton Inn By Hilton Dexter
Hampton Inn By Hilton DexterDexter
10.0 out of 10, Exceptional, (8 reviews)
The price is CNY737
CNY828 total
includes taxes & fees
Jan 24 - Jan 25

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (336 reviews)
cleanliness Charming lodge in Ozark Mountain country with hiking trails and free amenities.
The price is CNY627
CNY680 total
includes taxes & fees
Jan 25 - Jan 26

Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (175 reviews)
cleanliness Relax by the pool in Ironton, with historic sites and train station just minutes away.
The price is CNY801
CNY875 total
includes taxes & fees
Jan 21 - Jan 22

Pear Tree Inn Sikeston
Pear Tree Inn SikestonSikeston
9.4 out of 10, Exceptional, (1,003 reviews)
cleanliness Quiet, dual pool paradise near Central Park in charming Sikeston.
The price is CNY522
CNY601 total
includes taxes & fees
Jan 21 - Jan 22
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Jan 17 - Jan 18
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9.6 out of 10, Exceptional, (84 reviews)
We have 8 left at
The price is CNY672
per night
CNY732 total
includes taxes & fees
Showing deals for:Jan 18 - Jan 19
We have 6 left at
The price is CNY797
per night
CNY899 total
includes taxes & fees
Showing deals for:Jan 23 - Jan 25

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (688 reviews)
CNY253 off
The price is CNY717
per night
CNY1,552 total
includes taxes & fees
Check out hotels with a hot tub in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1007)
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22
You may also like pet-friendly hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1007)
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22
You can also stay at hotels with a pool in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1007)
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Southeast Missouri
Family friendly
Top landmarks in Central United States
Learn more about Southeast Missouri
Southeast Missouri is well-known for its wineries and riverfront while attractions include K Bridge Recreation Area and Lake Wappapello State Park. This family-friendly city has something for everyone including its university life, restaurants, and sights like Clearwater Lake and Lake Wappapello.

Photo by Bill Dillard
Open Photo by Bill Dillard
Check out reviews of Southeast Missouri hotels guests love

Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
Frequently asked questions
Keep exploring
- Perryville Hotels
- Hotels near Missouri's National Veterans Memorial
- Qulin Hotels
- Doniphan Hotels
- Hotels with Parking in Ironton
- Hotels with Free Breakfast in Sikeston
- Hotels near St. Francois State Park
- Cobalt Hotels
- Cheap Hotels in Cape Girardeau
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- Hotels with a Pool in Poplar Bluff
- Fisk Hotels
- Williamsville Hotels
- Caledonia Hotels
- Motels in Farmington
- Cheap Hotels in Sikeston
- Hotels near Sikeston Memorial Municipal
- Ste. Genevieve County Hotels
- Oak Ridge Hotels
- Hotels near Malden Regional
- Hotels near Saint Francis Healthcare System
- Poplar Bluff Hotels
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