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Hotels in Southeast Missouri
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The Farmstead Hotel
The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
8.8/10
Excellent
(463)
cleanliness Serene and well-maintained riverfront property with gaming excitement and quiet comfort.
The price is CNY602
CNY602
CNY685 total
includes taxes & fees
Dec 24 - Dec 25




Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1005)
8.4/10
Very Good
(1005)
cleanliness Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.
The price is CNY532
CNY532
CNY607 total
includes taxes & fees
Dec 21 - Dec 22




Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
cleanliness Quiet, dual pool paradise near Central Park in charming Sikeston.
The price is CNY528
CNY528
CNY607 total
includes taxes & fees
Dec 23 - Dec 24




Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
6.6/10
(612)
cleanliness Gateway to historic Charleston with easy interstate access and free breakfast.
The price is CNY437
CNY437
CNY485 total
includes taxes & fees
Jan 16 - Jan 17, 2026




Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
8.4/10
Very Good
(719)
cleanliness Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.
The price is CNY391
CNY391
CNY445 total
includes taxes & fees
Dec 21 - Dec 22




Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
9.6/10
Exceptional
(1004)
cleanliness Quiet escape near Cape Girardeau with an indoor pool for year-round enjoyment.
The price is CNY584
CNY584
CNY618 total
includes taxes & fees
Dec 25 - Dec 26




La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (669)
8.8/10
Excellent
(669)
The price is CNY593
CNY593
CNY641 total
includes taxes & fees
Dec 20 - Dec 21




Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1000)
7.8/10
Good
(1000)
cleanliness Experience clean comfort near North Main Street Historic District and art museum.
The price is CNY535
CNY535
CNY564 total
includes taxes & fees
Dec 21 - Dec 22




Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
8.6/10
Excellent
(443)
cleanliness Convenient stay near Central Park with refreshing pool and complimentary perks.
The price is CNY655
CNY655
CNY741 total
includes taxes & fees
Jan 11 - Jan 12, 2026




Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
9.4/10
Exceptional
(855)
cleanliness Relax at the stylish riverside hotel with 24-hour fitness and indoor pool access.
The price is CNY730
CNY730
CNY825 total
includes taxes & fees
Jan 4 - Jan 5, 2026




New Orleans Inn Portageville
New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (726)
8.0/10
Very Good
(726)
cleanliness Comfortable motel near Cape Girardeau with free WiFi and helpful 24-hour service.




Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
8.6/10
Excellent
(331)
cleanliness Charming lodge in Ozark Mountain country with hiking trails and free amenities.
The price is CNY672
CNY672
CNY728 total
includes taxes & fees
Dec 21 - Dec 22




Shepherd Mountain Inn
Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
9.4/10
Exceptional
(304)
cleanliness Enjoy a peaceful mountain escape with bar, restaurant, and nearby hiking trails.




Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.6 out of 10, (564)
6.6/10
(564)
cleanliness Convenient Sikeston escape with free amenities and easy access to local attractions.
The price is CNY418
CNY418
CNY477 total
includes taxes & fees
Dec 21 - Dec 22




La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (886)
8.0/10
Very Good
(886)
cleanliness Tranquil hotel close to Jorkerst Memorial Park offers free breakfast and parking.
The price is CNY652
CNY652
CNY746 total
includes taxes & fees
Jan 8 - Jan 9, 2026




Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (445)
9.0/10
Wonderful
(445)
cleanliness Discover contemporary comfort with an indoor pool just off I-55 in Sikeston.
The price is CNY687
CNY687
CNY778 total
includes taxes & fees
Dec 28 - Dec 29




Town House Inn
Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (423)
7.6/10
Good
(423)
cleanliness Comfortable Jackson motel near Litz Park with free parking and helpful staff.
The price is CNY494
CNY494
CNY535 total
includes taxes & fees
Dec 23 - Dec 24




Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
6.8/10
(406)
The price is CNY463
CNY463
CNY514 total
includes taxes & fees
Dec 31 - Jan 1, 2026




Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
9.4/10
Exceptional
(1000)
cleanliness Relaxing indoor pool hotel minutes from Cape Splash and historic Fort D sites.
The price is CNY669
CNY669
CNY755 total
includes taxes & fees
Dec 25 - Dec 26




Current River Inn
Current River Inn
3.0 star property
Van Buren
8.2 out of 10, Very Good, (165)
8.2/10
Very Good
(165)
cleanliness Riverside retreat with seasonal outdoor pool and free WiFi in scenic Van Buren.
The price is CNY652
CNY652
CNY705 total
includes taxes & fees
Dec 29 - Dec 30
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Great weekend hotel deals in Southeast Missouri, MO
Showing deals for:Dec 26 - Dec 28
Image gallery for The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4/10Exceptional (474 reviews)
10% off
Price is CNY805
CNY805
CNY1,816 total
CNY1,816 total
includes taxes & fees includes taxes & fees
Image gallery for Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6/10Excellent (331 reviews)
15% off
Price is CNY634
CNY634
CNY1,375 total
CNY1,375 total
includes taxes & fees includes taxes & fees
Image gallery for Current River Inn

Current River Inn
3.0 star property
Van Buren
8.2/10Very Good (165 reviews)
10% off
Price is CNY652
CNY652
CNY1,411 total
CNY1,411 total
includes taxes & fees includes taxes & fees
Image gallery for Century Casino & Hotel Caruthersville

Century Casino & Hotel Caruthersville
2.0 star property
Caruthersville
8.6/10Excellent (103 reviews)
10% off
Price is CNY856
CNY856
CNY1,946 total
CNY1,946 total
includes taxes & fees includes taxes & fees
Image gallery for La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0/10Very Good (886 reviews)
Price is CNY847
CNY847
CNY1,937 total
CNY1,937 total
includes taxes & fees includes taxes & fees
Image gallery for Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10/10Exceptional (18 reviews)
10% off
Price is CNY1,270
CNY1,270
CNY2,865 total
CNY2,865 total
includes taxes & fees includes taxes & fees
Image gallery for The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8/10Excellent (463 reviews)
10% off
Price is CNY602
CNY602
CNY1,369 total
CNY1,369 total
includes taxes & fees includes taxes & fees
Image gallery for EC Reed's Mercantile and Hotel

VIP Access
EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6/10Exceptional (83 reviews)
10% off
Price is CNY815
CNY815
CNY1,774 total
CNY1,774 total
includes taxes & fees includes taxes & fees
Image gallery for La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8/10Excellent (669 reviews)
20% off
Price is CNY620
CNY620
CNY1,341 total
CNY1,341 total
includes taxes & fees includes taxes & fees
Image gallery for Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4/10Exceptional (304 reviews)
10% off
Price is CNY868
CNY868
CNY1,897 total
CNY1,897 total
includes taxes & fees includes taxes & fees
Image gallery for Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4/10Very Good (282 reviews)
20% off
Price is CNY586
CNY586
CNY1,335 total
CNY1,335 total
includes taxes & fees includes taxes & fees
Image gallery for Triangle Inn Motel

Triangle Inn Motel
2.0 star property
Ste Genevieve
8.0/10Very Good (42 reviews)
10% off
Price is CNY539
CNY539
CNY1,202 total
CNY1,202 total
includes taxes & fees includes taxes & fees
Image gallery for Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2/10Very Good (739 reviews)
20% off
Price is CNY648
CNY648
CNY1,402 total
CNY1,402 total
includes taxes & fees includes taxes & fees
Image gallery for New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0/10Very Good (726 reviews)
10% off
Price is CNY463
CNY463
CNY999 total
CNY999 total
includes taxes & fees includes taxes & fees
Budget hotels in Southeast Missouri and vicinity




7.0 out of 10, Good, (68)
7.0/10
Good
(68)
The price is CNY302
CNY302
CNY369 total
includes taxes & fees
Dec 24 - Dec 25




7.0 out of 10, Good, (538)
7.0/10
Good
(538)
The price is CNY353
CNY353
CNY386 total
includes taxes & fees
Dec 20 - Dec 21




7.6 out of 10, Good, (862)
7.6/10
Good
(862)
The price is CNY359
CNY359
CNY429 total
includes taxes & fees
Jan 4 - Jan 5, 2026




8.0 out of 10, Very Good, (726)
8.0/10
Very Good
(726)




8.0 out of 10, Very Good, (612)
8.0/10
Very Good
(612)
The price is CNY371
CNY371
CNY423 total
includes taxes & fees
Dec 30 - Dec 31




Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO2.5 star property
Farmington
8.0 out of 10, Very Good, (1000)
8.0/10
Very Good
(1000)
The price is CNY372
CNY372
CNY423 total
includes taxes & fees
Jan 2 - Jan 3, 2026




Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
8.4/10
Very Good
(719)
The price is CNY391
CNY391
CNY445 total
includes taxes & fees
Dec 21 - Dec 22




7.0 out of 10, Good, (379)
7.0/10
Good
(379)
The price is CNY389
CNY389
CNY425 total
includes taxes & fees
Dec 21 - Dec 22




7.8 out of 10, Good, (39)
7.8/10
Good
(39)
The price is CNY406
CNY406
CNY464 total
includes taxes & fees
Dec 24 - Dec 25




7.2 out of 10, Good, (684)
7.2/10
Good
(684)
The price is CNY406
CNY406
CNY458 total
includes taxes & fees
Dec 25 - Dec 26




8.4 out of 10, Very Good, (938)
8.4/10
Very Good
(938)
The price is CNY443
CNY443
CNY507 total
includes taxes & fees
Dec 28 - Dec 29




Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
7.2/10
Good
(1001)
The price is CNY443
CNY443
CNY505 total
includes taxes & fees
Dec 21 - Dec 22




7.0 out of 10, Good, (332)
7.0/10
Good
(332)
The price is CNY475
CNY475
CNY534 total
includes taxes & fees
Jan 1 - Jan 2, 2026




8.0 out of 10, Very Good, (42)
8.0/10
Very Good
(42)
The price is CNY539
CNY539
CNY601 total
includes taxes & fees
Dec 31 - Jan 1, 2026




Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (882)
8.2/10
Very Good
(882)
The price is CNY542
CNY542
CNY650 total
includes taxes & fees
Jan 19 - Jan 20, 2026




Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
9.0/10
Wonderful
(1002)
The price is CNY493
CNY493
CNY556 total
includes taxes & fees
Jan 10 - Jan 11, 2026




9.0 out of 10, Wonderful, (1000)
9.0/10
Wonderful
(1000)
The price is CNY493
CNY493
CNY556 total
includes taxes & fees
Jan 11 - Jan 12, 2026




7.6 out of 10, Good, (423)
7.6/10
Good
(423)
The price is CNY494
CNY494
CNY535 total
includes taxes & fees
Dec 23 - Dec 24




8.0 out of 10, Very Good, (1007)
8.0/10
Very Good
(1007)
The price is CNY509
CNY509
CNY585 total
includes taxes & fees
Dec 29 - Dec 30




8.4 out of 10, Very Good, (1005)
8.4/10
Very Good
(1005)
The price is CNY532
CNY532
CNY607 total
includes taxes & fees
Dec 21 - Dec 22
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out hotels with a hot tub in Southeast Missouri




8.0 out of 10, Very Good, (726)
8.0/10
Very Good
(726)




9.6 out of 10, Exceptional, (1004)
9.6/10
Exceptional
(1004)
The price is CNY584
CNY584
CNY618 total
includes taxes & fees
Dec 25 - Dec 26




9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY528
CNY528
CNY607 total
includes taxes & fees
Dec 23 - Dec 24




Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is CNY634
CNY634
CNY715 total
includes taxes & fees
Jan 11 - Jan 12, 2026




9.2 out of 10, Wonderful, (965)
9.2/10
Wonderful
(965)
The price is CNY662
CNY662
CNY748 total
includes taxes & fees
Dec 25 - Dec 26




Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature Collection2.5 star property
Farmington
9.0 out of 10, Wonderful, (575)
9.0/10
Wonderful
(575)
The price is CNY697
CNY697
CNY794 total
includes taxes & fees
Dec 28 - Dec 29




6.6 out of 10, (124)
6.6/10
(124)
The price is CNY488
CNY488
CNY559 total
includes taxes & fees
Dec 28 - Dec 29




9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
The price is CNY634
CNY634
CNY715 total
includes taxes & fees
Jan 11 - Jan 12, 2026




8.8 out of 10, Excellent, (518)
8.8/10
Excellent
(518)
The price is CNY756
CNY756
CNY861 total
includes taxes & fees
Dec 25 - Dec 26




Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville3.0 star property
Hayti
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY662
CNY662
CNY754 total
includes taxes & fees
Jan 3 - Jan 4, 2026
You may also like pet-friendly hotels in Southeast Missouri




9.2 out of 10, Wonderful, (965)
9.2/10
Wonderful
(965)
The price is CNY662
CNY662
CNY748 total
includes taxes & fees
Dec 25 - Dec 26




Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is CNY634
CNY634
CNY715 total
includes taxes & fees
Jan 11 - Jan 12, 2026




9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY634
CNY634
CNY729 total
includes taxes & fees
Dec 23 - Dec 24




9.6 out of 10, Exceptional, (83)
9.6/10
Exceptional
(83)




Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
8.4/10
Very Good
(719)
The price is CNY391
CNY391
CNY445 total
includes taxes & fees
Dec 21 - Dec 22




8.4 out of 10, Very Good, (1005)
8.4/10
Very Good
(1005)
The price is CNY532
CNY532
CNY607 total
includes taxes & fees
Dec 21 - Dec 22




9.6 out of 10, Exceptional, (217)
9.6/10
Exceptional
(217)
The price is CNY1,120
CNY1,120
CNY1,184 total
includes taxes & fees
Dec 21 - Dec 22




Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1002)
9.0/10
Wonderful
(1002)
The price is CNY493
CNY493
CNY556 total
includes taxes & fees
Jan 10 - Jan 11, 2026




9.4 out of 10, Exceptional, (796)
9.4/10
Exceptional
(796)
The price is CNY704
CNY704
CNY789 total
includes taxes & fees
Jan 18 - Jan 19, 2026




9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY528
CNY528
CNY607 total
includes taxes & fees
Dec 23 - Dec 24
You can also stay at family-friendly hotels in Southeast Missouri




7.8 out of 10, Good, (1000)
7.8/10
Good
(1000)
The price is CNY535
CNY535
CNY564 total
includes taxes & fees
Dec 21 - Dec 22




La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau3.0 star property
Jackson
8.8 out of 10, Excellent, (669)
8.8/10
Excellent
(669)
The price is CNY593
CNY593
CNY641 total
includes taxes & fees
Dec 20 - Dec 21




Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is CNY634
CNY634
CNY715 total
includes taxes & fees
Jan 11 - Jan 12, 2026




9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY528
CNY528
CNY607 total
includes taxes & fees
Dec 23 - Dec 24




9.2 out of 10, Wonderful, (965)
9.2/10
Wonderful
(965)
The price is CNY662
CNY662
CNY748 total
includes taxes & fees
Dec 25 - Dec 26




Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO2.0 star property
Charleston
6.6 out of 10, (612)
6.6/10
(612)
The price is CNY437
CNY437
CNY485 total
includes taxes & fees
Dec 25 - Dec 26




7.8 out of 10, Good, (911)
7.8/10
Good
(911)
The price is CNY533
CNY533
CNY622 total
includes taxes & fees
Dec 21 - Dec 22




6.8 out of 10, (406)
6.8/10
(406)
The price is CNY463
CNY463
CNY514 total
includes taxes & fees
Dec 31 - Jan 1, 2026




7.6 out of 10, Good, (862)
7.6/10
Good
(862)
The price is CNY359
CNY359
CNY429 total
includes taxes & fees
Jan 4 - Jan 5, 2026




9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
The price is CNY634
CNY634
CNY729 total
includes taxes & fees
Dec 23 - Dec 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Southeast Missouri
Family friendly
Cottage
Pet friendly
Top landmarks in Central United States
Learn more about Southeast Missouri
Southeast Missouri is well-known for its wineries and riverfront while attractions include K Bridge Recreation Area and Lake Wappapello State Park. This family-friendly city has something for everyone including its university life, restaurants, and sights like Clearwater Lake and Lake Wappapello.

Photo by Bill Dillard
Open Photo by Bill Dillard
Check out reviews of Southeast Missouri hotels guests love

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
10/10 Excellent
"Breakfast was great!
Location right off interstate was perfect.
The property is a little old."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Very clean premises, easy check-in, quiet, good breakfast and Wendy, the receptionist was the BEST ever in providing professional, quality and attentive customer service with a smile and warm welcome!"

The Farmstead Hotel
10/10 Excellent
"Nice place "

The Riverview
10/10 Excellent
"The room was clean and the mattress was extremely comfortable "

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"It was amazing check in to check out"

Drury Inn & Suites Jackson MO
10/10 Excellent
"Yes"

Holiday Inn Poplar Bluff by IHG
10/10 Excellent
"The room was clean, comfortable, cozy. "

Drury Inn & Suites Sikeston, MO
10/10 Excellent
"Clean room, friendly staff"

Motel 6 Poplar Bluff, MO
10/10 Excellent
"Staff was amazing and super nice. Room was very clean. "
Frequently asked questions
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
Keep exploring
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- Qulin Hotels
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- Hotels with Parking in Ironton
- Hotels with Free Breakfast in Sikeston
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