Photo by Henry Fitzthum

Hotels in Southeast Missouri

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Southeast Missouri?

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,007 reviews)
  • cleanliness
    Explore the stunning forest views with free breakfast, indoor pool, and dining options.
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,003 reviews)
  • cleanliness
    Peaceful highway-adjacent retreat with indoor and outdoor pool options.
The price is CNY655
CNY753 total
includes taxes & fees
Jan 22 - Jan 23
Drury Inn & Suites Sikeston, MO
The Farmstead Hotel
The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (472 reviews)
  • cleanliness
    Serene and well-maintained riverfront property with gaming excitement and quiet comfort.
The price is CNY530
CNY602 total
includes taxes & fees
Jan 30 - Jan 31
The Farmstead Hotel
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1,000 reviews)
  • cleanliness
    Experience clean comfort near North Main Street Historic District and art museum.
The price is CNY397
CNY419 total
includes taxes & fees
Jan 20 - Jan 21
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (979 reviews)
  • cleanliness
    Relax in dual indoor-outdoor pool options in this Poplar Bluff tranquil retreat.
The price is CNY725
CNY819 total
includes taxes & fees
Feb 6 - Feb 7
Drury Inn & Suites Poplar Bluff
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (730 reviews)
  • cleanliness
    Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.
The price is CNY387
CNY441 total
includes taxes & fees
Jan 21 - Jan 22
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (151 reviews)
  • cleanliness
    Stay near Fort D Historic Site with a free breakfast and indoor pool.
The price is CNY613
CNY692 total
includes taxes & fees
Jan 25 - Jan 26
Fairfield Inn & Suites by Marriott Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (688 reviews)
The price is CNY557
CNY603 total
includes taxes & fees
Jan 25 - Jan 26
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
  • cleanliness
    Restful hotel near Cape Splash with indoor pool and complimentary amenities.
The price is CNY627
CNY707 total
includes taxes & fees
Jan 21 - Jan 22
Drury Inn & Suites Cape Girardeau
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,003 reviews)
  • cleanliness
    Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.
The price is CNY498
CNY567 total
includes taxes & fees
Jan 25 - Jan 26
Best Western Plus Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,003 reviews)
  • cleanliness
    Perfect location near medical center with helpful staff and peaceful atmosphere.
The price is CNY739
CNY833 total
includes taxes & fees
Jan 18 - Jan 19
Pear Tree Inn Cape Girardeau Near the Medical Center
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Quiet escape near Cape Girardeau with an indoor pool for year-round enjoyment.
The price is CNY578
CNY611 total
includes taxes & fees
Jan 19 - Jan 20
Drury Inn & Suites Jackson MO
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (578 reviews)
  • cleanliness
    Lakeside haven with championship golf and warm service at this serene retreat.
The price is CNY899
CNY1,023 total
includes taxes & fees
Jan 20 - Jan 21
Crown Pointe Lodge, BW Signature Collection
Echo Bluff State Park
Echo Bluff State Park
2.5 star property
Eminence
9.4 out of 10, Exceptional, (219 reviews)
  • cleanliness
    Explore nature's playground in Missouri's scenic Eminence wilderness.
The price is CNY1,143
CNY1,208 total
includes taxes & fees
Jan 19 - Jan 20
Echo Bluff State Park
Hampton Inn Poplar Bluff
Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (798 reviews)
  • cleanliness
    Experience a comfortable stay minutes from North Main Street Historic District.
The price is CNY755
CNY845 total
includes taxes & fees
Feb 14 - Feb 15
Hampton Inn Poplar Bluff
EC Reed's Mercantile and Hotel
EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84 reviews)
  • cleanliness
    Rustic hotel with hiking trails and free perks in the charming town of Marble Hill.
EC Reed's Mercantile and Hotel
Hampton Inn By Hilton Dexter
Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (8 reviews)
The price is CNY737
CNY828 total
includes taxes & fees
Jan 24 - Jan 25
Hampton Inn By Hilton Dexter
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (336 reviews)
  • cleanliness
    Charming lodge in Ozark Mountain country with hiking trails and free amenities.
The price is CNY627
CNY680 total
includes taxes & fees
Jan 25 - Jan 26
Honeysuckle Inn - Mountain View
Fort Davidson Hotel
Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (175 reviews)
  • cleanliness
    Relax by the pool in Ironton, with historic sites and train station just minutes away.
The price is CNY801
CNY875 total
includes taxes & fees
Jan 21 - Jan 22
Fort Davidson Hotel
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1,003 reviews)
  • cleanliness
    Quiet, dual pool paradise near Central Park in charming Sikeston.
The price is CNY522
CNY601 total
includes taxes & fees
Jan 21 - Jan 22
Pear Tree Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Get last-minute hotel deals in Southeast Missouri and save more

Sign in to unlock great savings.
Showing deals for:Jan 17 - Jan 18
Showing deals for:Jan 18 - Jan 19
Showing deals for:Jan 23 - Jan 25

Check out hotels with a hot tub in Southeast Missouri

You may also like pet-friendly hotels in Southeast Missouri

You can also stay at hotels with a pool in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Central United States

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include K Bridge Recreation Area and Lake Wappapello State Park. This family-friendly city has something for everyone including its university life, restaurants, and sights like Clearwater Lake and Lake Wappapello.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

Check out reviews of Southeast Missouri hotels guests love

Frequently asked questions

Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.