Photo by JG Morris

Hotels in Southeast Missouri

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Tonight
Dec 31 - Jan 1
Tomorrow
Jan 1 - Jan 2
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Where to stay in Southeast Missouri?

Property amenity
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1001)
  • cleanliness
    Peaceful highway-adjacent retreat with indoor and outdoor pool options.
The price is CNY630
CNY724 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Inn & Suites Sikeston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Jan 9 - Jan 11

Image gallery for Johnson's Shut-ins State Park

Full-size fridge, microwave, oven, stovetop

Johnson's Shut-ins State Park

3.0 star property
Middle Brook
10/10Exceptional (1 review)
Member Price available
Price is CNY1,861
CNY3,935 total
includes taxes & fees
Johnson's Shut-ins State Park

Budget hotels in Southeast Missouri and vicinity

Reception
OYO Malden Airport Inn

OYO Malden Airport Inn

OYO Malden Airport Inn
2.5 star property
Malden
7.0 out of 10, Good, (68)
The price is CNY341
CNY411 total
includes taxes & fees
Jan 6 - Jan 7, 2026
OYO Malden Airport Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out pet-friendly hotels in Southeast Missouri

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Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
The price is CNY630
CNY710 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
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You may also like family-friendly hotels in Southeast Missouri

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
The price is CNY630
CNY710 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
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You can also stay at hotels with a hot tub in Southeast Missouri

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
The price is CNY630
CNY710 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top landmarks in Central United States

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
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A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
Elephant Rocks State Park is 5.3 mi (8.5 km) from central Ironton, why not stop by during your stay.
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Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include K Bridge Recreation Area and Lake Wappapello State Park. This family-friendly city has something for everyone including its university life, restaurants, and sights like Clearwater Lake and Lake Wappapello.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Check out reviews of Southeast Missouri hotels guests love

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Everything was great "
Kimberly 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO

Frequently asked questions

Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.