Photo by Katie Irvin

Hotels in Southwest Oklahoma

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Tonight
Dec 21 - Dec 22
Tomorrow
Dec 22 - Dec 23
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

Where to stay in Southwest Oklahoma?

Exterior
La Quinta Inn & Suites by Wyndham Clinton Historic Route 66
La Quinta Inn & Suites by Wyndham Clinton Historic Route 66
3.0 star property
9.2 out of 10, Wonderful, (1003)
  • cleanliness
    Relax on historic Route 66 with a splash in the indoor pool and rejuvenating stay.
The price is CNY569
CNY651 total
includes taxes & fees
Jan 11 - Jan 12, 2026
La Quinta Inn & Suites by Wyndham Clinton Historic Route 66
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Southwest Oklahoma, OK

Showing deals for:Jan 2 - Jan 4

Image gallery for Fairfield Inn & Suites by Marriott Chickasha

Reception

Fairfield Inn & Suites by Marriott Chickasha

2.5 star property
Chickasha
9.0/10Wonderful (162 reviews)
15% off
Price is CNY682
CNY1,603 total
includes taxes & fees
Fairfield Inn & Suites by Marriott Chickasha

Budget hotels in Southwest Oklahoma and vicinity

Exterior
Relax Inn

Relax Inn

Relax Inn
2.5 star property
Clinton
9.8 out of 10, Exceptional, (6)
The price is CNY275
CNY357 total
includes taxes & fees
Dec 27 - Dec 28
Relax Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out pet-friendly hotels in Southwest Oklahoma

Reception
Century inn motel

Century inn motel

Century inn motel
2.5 star property
Marlow
7.8 out of 10, Good, (18)
The price is CNY425
CNY461 total
includes taxes & fees
Dec 22 - Dec 23
Century inn motel
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You may also like hotels with hot tubs in Southwest Oklahoma

Exterior
AmericInn by Wyndham Sayre

AmericInn by Wyndham Sayre

AmericInn by Wyndham Sayre
2.5 star property
Sayre
8.6 out of 10, Excellent, (550)
The price is CNY563
CNY647 total
includes taxes & fees
Jan 11 - Jan 12, 2026
AmericInn by Wyndham Sayre
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You can also stay at family-friendly hotels in Southwest Oklahoma

Exterior
AmericInn by Wyndham Sayre

AmericInn by Wyndham Sayre

AmericInn by Wyndham Sayre
2.5 star property
Sayre
8.6 out of 10, Excellent, (550)
The price is CNY563
CNY647 total
includes taxes & fees
Jan 11 - Jan 12, 2026
AmericInn by Wyndham Sayre
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Central United States

Sunset landscape with a full moon in Wichita Mountains National Wildlife Refuge

Wichita Mountains Wildlife Refuge

4.6/5 (287 reviews)
Wichita Mountains Wildlife Refuge is 11.2 mi (18.1 km) from central Indiahoma, why not stop by during your stay. Want to stretch your legs some more? Head to Wichita Mountains National Wildlife Refuge, located nearby.
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The Narrows. #hikes #hiking #oklahoma #wichita mountains
Photo by David Morring
Open Photo by David Morring

Wichita Mountains

4.6/5 (165 reviews)
If you want to stretch your legs and breathe in some fresh mountain air, head out to Wichita Mountains for a bird's-eye view of Lawton.
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Learn more about Southwest Oklahoma

Southwest Oklahoma is well-known for its casinos and university life, featuring attractions such as Caddo Lake and Wichita Mountains. Visitors highlight this family-friendly city's museums while sights include Wichita Mountains Wildlife Refuge and Lake Elmer Thomas Recreation Area.

See all hotels in Southwest Oklahoma
Dog Run Hollow trail hike.
Photo by Katie Irvin
Open Photo by Katie Irvin

Check out reviews of Southwest Oklahoma hotels guests love

Sleep Inn & Suites Lawton Near Fort Sill

Sleep Inn & Suites Lawton Near Fort Sill

10/10 Excellent
"Nice quiet room, good breakfast, room coildve used a fan to move the air."
Robert 1-night trip
Posted 1 day ago
Sleep Inn & Suites Lawton Near Fort Sill

Frequently asked questions

Why should I book my Southwest Oklahoma hotel through Hotels.com?
There are plenty of reasons to book your Southwest Oklahoma travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.