Hotels in South Main

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Jan 17 - Jan 18
Tomorrow
Jan 18 - Jan 19
Next weekend
Jan 23 - Jan 25
In two weeks
Jan 30 - Feb 1

Where to stay in South Main?

Premium bedding, pillowtop beds, in-room safe, individually decorated

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,206 reviews)
The price is CNY899
CNY1,052 total
includes taxes & fees
Jan 26 - Jan 27
Wyndham Houston near NRG Park/Medical Center
Lobby

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (996 reviews)
The price is CNY759
CNY889 total
includes taxes & fees
Jan 26 - Jan 27
Wingate Houston near NRG Park/Medical Center
Individually decorated, individually furnished, desk, laptop workspace

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,002 reviews)
The price is CNY596
CNY697 total
includes taxes & fees
Jan 18 - Jan 19
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,000 reviews)
The price is CNY528
CNY617 total
includes taxes & fees
Jan 25 - Jan 26
Quality Inn & Suites NRG Park - Medical Center
Exterior

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (829 reviews)
The price is CNY543
CNY636 total
includes taxes & fees
Jan 19 - Jan 20
Candlewood Suites Houston Medical Center by IHG
Lobby

Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,221 reviews)
The price is CNY767
CNY902 total
includes taxes & fees
Feb 6 - Feb 7
Hyatt House Houston Medical Center
Lobby

Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,259 reviews)
The price is CNY818
CNY962 total
includes taxes & fees
Feb 5 - Feb 6
Hyatt Place Houston Medical Center
Lobby

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,660 reviews)
The price is CNY1,023
CNY1,196 total
includes taxes & fees
Jan 23 - Jan 24
Blossom Hotel Houston, Curio Collection by Hilton
Free daily continental breakfast

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
1.4 km from South Main
9.4 out of 10, Exceptional, (1,003 reviews)
The price is CNY809
CNY952 total
includes taxes & fees
Jan 23 - Jan 24
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Bar (on property)

SpringHill Suites Houston Medical Center/NRG Park

SpringHill Suites Houston Medical Center/NRG Park
3.0 star property
Astrodome, 2.4 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
The price is CNY705
CNY825 total
includes taxes & fees
Feb 1 - Feb 2
SpringHill Suites Houston Medical Center/NRG Park
Terrace/patio

Home2 Suites by Hilton Houston Medical Center, TX

Home2 Suites by Hilton Houston Medical Center, TX
3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (588 reviews)
The price is CNY851
CNY996 total
includes taxes & fees
Jan 24 - Jan 25
Home2 Suites by Hilton Houston Medical Center, TX
Terrace/patio

Hilton Garden Inn Houston Medical Center, TX

Hilton Garden Inn Houston Medical Center, TX
3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1,001 reviews)
The price is CNY794
CNY929 total
includes taxes & fees
Jan 24 - Jan 25
Hilton Garden Inn Houston Medical Center, TX
Outdoor pool, free cabanas, pool umbrellas

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,056 reviews)
The price is CNY1,007
CNY1,254 total
includes taxes & fees
Jan 25 - Jan 26
The Westin Houston Medical Center/Museum District
Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1,321 reviews)
The price is CNY467
CNY546 total
includes taxes & fees
Jan 25 - Jan 26
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Presidential Suite, 1 King Bed | Premium bedding, in-room safe, desk, iron/ironing board

DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
6.6 km from South Main
8.4 out of 10, Very Good, (1,431 reviews)
The price is CNY794
CNY929 total
includes taxes & fees
Jan 24 - Jan 25
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Lobby

Sonesta ES Suites Houston Galleria

Sonesta ES Suites Houston Galleria
3.0 star property
The Galleria, 8.4 km from South Main
8.2 out of 10, Very Good, (1,149 reviews)
The price is CNY646
CNY755 total
includes taxes & fees
Jan 24 - Jan 25
Sonesta ES Suites Houston Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
8.7 km from South Main
9.0 out of 10, Wonderful, (1,203 reviews)
The price is CNY1,059
CNY1,452 total
includes taxes & fees
Jan 30 - Jan 31
Hyatt Regency Houston/Galleria
Terrace/patio

Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,003 reviews)
The price is CNY850
CNY994 total
includes taxes & fees
Feb 15 - Feb 16
Holiday Inn Express Houston - Galleria Area by IHG
Suite, 1 Bedroom | In-room safe, desk, blackout drapes, iron/ironing board

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1,338 reviews)
The price is CNY899
CNY1,056 total
includes taxes & fees
Jan 23 - Jan 24
Hyatt Place Houston/Galleria
Outdoor pool

Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,274 reviews)
The price is CNY627
CNY734 total
includes taxes & fees
Jan 25 - Jan 26
Drury Inn & Suites Houston Near the Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

When is the best time to visit South Main?

Our prices for hotels in South Main are cheapest in February
Price trends for hotels in South Main
Pricing is based on two traveler single night rates
View properties in January
Currently viewing crowd sizes and weather for January.
Typical weather for Houston
January
High 17°C / low 8°C. Sunny most days.
View properties in January
17°
weather_sun
January, no crowd data, average high temperature 17 degrees Celsius, average low temperature 8 degrees Celsius. Sunny most days.
8°
19°
weather_cloudy
February, no crowd data, average high temperature 19 degrees Celsius, average low temperature 10 degrees Celsius. Cloudy most days.
10°
23°
weather_sun
March, no crowd data, average high temperature 23 degrees Celsius, average low temperature 14 degrees Celsius. Sunny most days.
14°
26°
weather_sun
April, no crowd data, average high temperature 26 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
30°
weather_sun
May, no crowd data, average high temperature 30 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
33°
weather_sun
June, no crowd data, average high temperature 33 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
34°
weather_sun
July, no crowd data, average high temperature 34 degrees Celsius, average low temperature 25 degrees Celsius. Sunny most days.
25°
34°
weather_sun
August, no crowd data, average high temperature 34 degrees Celsius, average low temperature 26 degrees Celsius. Sunny most days.
26°
32°
weather_sun
September, no crowd data, average high temperature 32 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
28°
weather_sun
October, no crowd data, average high temperature 28 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
19°
22°
weather_sun
November, no crowd data, average high temperature 22 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
13°
18°
weather_sun
December, no crowd data, average high temperature 18 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
10°
Monthly weather averages (˚C)

Check out reviews of South Main hotels guests love

Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG

10/10 Excellent
"Good "
Dion 2-night trip
Posted 18 hours ago
Holiday Inn Houston Downtown by IHG

Frequently asked questions

Is South Main expensive to stay in?
You can find great hotels from CNY546 in South Main to suit a range of budgets. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for South Main hotels?
Discover great deals on hotels in South Main with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on South Main hotels.
Can I receive a refund if I cancel my South Main hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some South Main hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
What are some of the best pet-friendly hotels in South Main?
Traveling with your pet doesn't mean sacrificing a great hotel stay. In South Main, our travelers love:
What are some of the best South Main hotels for couples?
One of the best South Main hotels for couples is Wingate Houston near NRG Park/Medical Center. Wingate Houston near NRG Park/Medical Center is a popular hotel with an outdoor pool. Find more romantic South Main hotels by using the "Traveler experience" filter in your search and selecting "Adults only" or "Romantic".
What are some of the best South Main hotels with a pool?
Book a South Main hotel with a pool for some added relaxation or exercise on your trip. Wyndham Houston near NRG Park/Medical Center is a top-rated hotel with an outdoor pool, and an average guest score of 7.2 out of 10. This hotel also features a restaurant and a bar/lounge. Wingate Houston near NRG Park/Medical Center is another great hotel that features an outdoor pool, along with a free continental breakfast and a gym. For more South Main hotels with a pool, use the "Amenities" filter in your search and select "Pool" on Hotels.com.
Is it worth staying in South Main?
You're spoilt for choice with 64 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in South Main makes it easy to explore Houston, including the neighborhoods of The Galleria and Texas Medical Center.
Which station is best for South Main?
The main station in South Main is Fannin South Station. If you're staying at a hotel in South Main, check out the nearest station so that you can get around and explore with ease.
Find out more about South Main

Keep exploring