Hotels in Santa Isabel

Free cancellation options if plans change

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Check prices for these dates

Tonight
Dec 17 - Dec 18
Tomorrow
Dec 18 - Dec 19
This weekend
Dec 19 - Dec 21
Next weekend
Dec 26 - Dec 28

Where to stay in Santa Isabel?

Exterior
Trips Guna Yala
Trips Guna Yala
2.0 star property
The price is CNY729
CNY1,693 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Trips Guna Yala
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out reviews of Santa Isabel hotels guests love

Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

10/10 Excellent
"Very nice. And I liked the food "
Christopher 1-night trip
Posted 5 months ago
Private Over the Water Cabin on San Blas Island

Frequently asked questions

How much does a hotel room cost in Santa Isabel?
You can discover great hotels in Santa Isabel from CNY1,693 with properties to suit all budgets and needs. To find an affordable hotel in Santa Isabel that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at Santa Isabel hotels?
Discover great deals on Santa Isabel hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. And make sure to check out our last-minute deals on Santa Isabel hotels.
Can I book Santa Isabel hotels with free cancellation?
In order to book a refundable Santa Isabel hotel, simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
Can I book a refundable accommodation in Santa Isabel?
If you need the flexibility to change your plans to Santa Isabel, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Isabel be like during my vacation?
With an average temperature of 78°F during the coldest months, Santa Isabel is a great place to visit any time of year.
Why should I book my Santa Isabel accommodation with Hotels.com?
There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.