Hotels near Mayo Clinic Florida Jacksonville

Q: What are the best hotels near Mayo Clinic Florida?

Guests love staying at Hilton Jacksonville At Mayo Clinic , which is a hotel near Mayo Clinic Florida. Also highly rated is Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches , which is just steps away. With 7,481 hotels, vacation rentals, and other accommodations in the area, you'll have plenty to choose from.

Q: Which hotels near Mayo Clinic Florida have rooms with great views?

At Hilton Jacksonville At Mayo Clinic , there are rooms where you can take in the water views. The hotel is steps from Mayo Clinic Florida. Also recommended is Ponte Vedra Inn & Club , which has rooms with ocean or golf views.

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January 2026

February 2026

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Where to stay near Mayo Clinic Florida?

Breakfast, lunch, dinner served; American cuisine

Hilton Jacksonville At Mayo Clinic

0.8 km from Mayo Clinic Florida

CNY1,421 total

includes taxes & fees

Jan 29 - Jan 30

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

CNY1,455 total

includes taxes & fees

Jan 23 - Jan 24

TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

CNY901 total

includes taxes & fees

Feb 1 - Feb 2

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

CNY870 total

includes taxes & fees

Jan 25 - Jan 26

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

CNY1,273 total

includes taxes & fees

Jan 24 - Jan 25

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

CNY901 total

includes taxes & fees

Jan 30 - Jan 31

Salt Air Inn & Suites

7.8 km from Mayo Clinic Florida

TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

CNY988 total

includes taxes & fees

Jan 25 - Jan 26

Element Jacksonville Beach

5.4 km from Mayo Clinic Florida

CNY933 total

includes taxes & fees

Feb 8 - Feb 9

Standard Room, 2 Queen Beds, Non Smoking | Down comforters, minibar, iron/ironing board, WiFi

The Hotel Palms

7.8 km from Mayo Clinic Florida

CNY1,336 total

includes taxes & fees

Jan 18 - Jan 19

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

CNY1,012 total

includes taxes & fees

Jan 25 - Jan 26

Couples treatment rooms, sauna, hot tub, steam room, body treatments

Ponte Vedra Inn & Club

6.3 km from Mayo Clinic Florida

CNY3,302 total

includes taxes & fees

Jan 19 - Jan 20

The Lodge and Club at Ponte Vedra Beach

6.3 km from Mayo Clinic Florida

CNY3,302 total

includes taxes & fees

Jan 25 - Jan 26

AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

CNY1,574 total

includes taxes & fees

Jan 19 - Jan 20

2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, sun loungers

Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

CNY1,077 total

includes taxes & fees

Jan 23 - Jan 24

Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

CNY1,068 total

includes taxes & fees

Jan 25 - Jan 26

Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

CNY1,060 total

includes taxes & fees

Jan 19 - Jan 20

Sheraton Jacksonville Hotel

Deerwood, 9.6 km from Mayo Clinic Florida

CNY907 total

includes taxes & fees

Jan 30 - Jan 31

Springhill Suites By Marriott Jacksonville Beach Oceanfront

5.8 km from Mayo Clinic Florida

CNY1,336 total

includes taxes & fees

Jan 25 - Jan 26

Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

CNY1,004 total

includes taxes & fees

Jan 19 - Jan 20

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Other landmarks near Mayo Clinic Florida

Adventure Landing

4.1/5 (157 reviews)

If thrills are what you're after, head to Adventure Landing, located 1 mi (1.7 km) from central Jacksonville Beach. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. If you have fun at Adventure Landing, you'll love Oceanfront Park, located nearby.

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Windsor Parke Golf Club

You might want to practice your swing at Windsor Parke Golf Club, a golf course located 12.3 mi (19.8 km) from central Jacksonville. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. If Windsor Parke Golf Club doesn't quite scratch your golfing itch, Jacksonville Beach Golf Club, and Harbor City Municipal Golf Course are also nearby.

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Harbor City Municipal Golf Course

You might want to play some rounds at Harbor City Municipal Golf Course, located 14.3 mi (23 km) from central Jacksonville. Why not take a stroll along the beaches and watch the sunset while you're here? If Harbor City Municipal Golf Course doesn't quite scratch your golfing itch, Jacksonville Beach Golf Club, and TPC Sawgrass are also nearby.

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Jacksonville Beach Golf Club

3.9/5 (58 reviews)

You might want to play some rounds at Jacksonville Beach Golf Club, located 0.5 mi (0.8 km) from central Jacksonville Beach. Hotels.com travelers also say the area is great for couples and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If Jacksonville Beach Golf Club doesn't quite scratch your golfing itch, Windsor Parke Golf Club, and Lagoon Course at Ponte Vedra Inn Club are also nearby.

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Frequently asked questions

What are the best hotels near Mayo Clinic Florida?

Guests love staying at Hilton Jacksonville At Mayo Clinic, which is a hotel near Mayo Clinic Florida.
Also highly rated is Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, which is just steps away.
With 7,481 hotels, vacation rentals, and other accommodations in the area, you'll have plenty to choose from.

How much does it cost to stay in a hotel near Mayo Clinic Florida?

On Hotels.com, you can find a variety of room prices depending on when and where you plan to go. Simply sort by price on the search results and filter by your preferred criteria to find the best options for you and your budget.

Search for the lowest price per night from CNY870

What cheap hotels are close to Mayo Clinic Florida?

Quality Inn Atlantic Beach - Mayo Clinic Jax Area is a budget-friendly hotel near Mayo Clinic Florida and offers a free full breakfast, free parking, and free in-room WiFi.
A second low-cost choice is Wyndham Garden Jacksonville, which is a short drive away.

Can I find hotels close to Mayo Clinic Florida that are fully refundable?

Yes, you'll find many hotels that offer refundable room rates as long as you cancel by the cancellation deadline. Find refundable rates using the "Fully refundable" filter when you search for hotels.

A couple of highly rated hotels close to Mayo Clinic Florida that offer these rates are Ponte Vedra Inn & Club and The Lodge and Club at Ponte Vedra Beach.

What are the best romantic hotels near Mayo Clinic Florida?

For a romantic stay, Hilton Jacksonville At Mayo Clinic offers a restaurant, an outdoor pool, and proposal/romance packages. It's steps from Mayo Clinic Florida.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area is another great choice, and it's just steps away.

What are the best hotels close to Mayo Clinic Florida with free breakfast?

Begin your day with a free buffet breakfast at Residence Inn By Marriott Jacksonville - Mayo Clinic Area, which is steps from Mayo Clinic Florida.
Azaleana Manor is also a recommended place to stay with a free continental breakfast, and it's located 30 minutes away by car.

Which hotels near Mayo Clinic Florida have rooms with great views?

At Hilton Jacksonville At Mayo Clinic, there are rooms where you can take in the water views. The hotel is steps from Mayo Clinic Florida.
Also recommended is Ponte Vedra Inn & Club, which has rooms with ocean or golf views.

What are the best family hotels close to Mayo Clinic Florida?

Keep the family happy with a stay at Hilton Jacksonville At Mayo Clinic which offers free cribs, children's meals, and an outdoor pool. Mayo Clinic Florida is just steps away.
Also consider Ponte Vedra Inn & Club as another great choice for your family's trip.

What are the best luxury hotels near Mayo Clinic Florida?

Pamper yourself with a stay at Hilton Jacksonville At Mayo Clinic, which is steps from Mayo Clinic Florida. This hotel features a restaurant called Coastal Kitchen, and offers an outdoor pool.
A second luxurious choice is Ponte Vedra Inn & Club, which is a short drive away.

What are the best hotels near Mayo Clinic Florida with free parking?

Drive and park with ease when you stay at Hilton Jacksonville At Mayo Clinic, which offers free parking. You'll be steps from Mayo Clinic Florida.
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches also has free parking and is just steps away.

What are the best hotels near Mayo Clinic Florida with a pool?

Travelers can enjoy the outdoor pool at Hilton Jacksonville At Mayo Clinic. Mayo Clinic Florida is steps from the hotel.
Another great choice for a hotel with a pool is Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches.

What cheap motels can I book close to Mayo Clinic Florida?

To save on your stay near Mayo Clinic Florida, take a look at Salt Air Inn & Suites, which offers an outdoor pool and a free local cuisine breakfast.
Studio 6 Jacksonville, FL - Baymeadows is another affordable motel to consider in the area.

What are the best things to see and do around my hotel near Mayo Clinic Florida?

Before or after your visit to Mayo Clinic Florida, you can check out nearby sights like St. Johns Town Center, TPC Sawgrass, and Jacksonville Beach Pier.
Other places in the area are Kathryn Abbey Hanna Park, UNF Arena, and The Avenues.

What are the best pet-friendly hotels close to Mayo Clinic Florida?

Your pet companion can join you at Residence Inn By Marriott Jacksonville - Mayo Clinic Area, which is steps from Mayo Clinic Florida.
One Ocean Resort and Spa is another pet-friendly option.

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Lodging

Hotels near Mayo Clinic Florida Jacksonville

Room 1

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay near Mayo Clinic Florida?

Hilton Jacksonville At Mayo Clinic

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Salt Air Inn & Suites

TownePlace Suites by Marriott® Jacksonville Mayport

Element Jacksonville Beach

The Hotel Palms

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Ponte Vedra Inn & Club

The Lodge and Club at Ponte Vedra Beach

AC Hotel Jacksonville St Johns Town Center

Hampton Inn Jacksonville Beach/Oceanfront

Hyatt Place Jacksonville / St. Johns Town Center

Margaritaville Jacksonville Beach

Sheraton Jacksonville Hotel

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Hotel Indigo Jacksonville-Deerwood Park by IHG

Other landmarks near Mayo Clinic Florida

Adventure Landing

Windsor Parke Golf Club

Windsor Commons Shopping Center

Harbor City Municipal Golf Course

Cradle Creek Preserve

Jacksonville Beach Golf Club

South Beach Park and Sunshine Playground

Gonzales Park

Frequently asked questions

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