Hotels near Mayo Clinic Florida Jacksonville
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay near Mayo Clinic Florida?
Hilton Jacksonville At Mayo Clinic
Hilton Jacksonville At Mayo Clinic4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (82)
9.4/10
Exceptional
(82)
The price is CNY1,034
CNY1,034
CNY1,173 total
includes taxes & fees
Dec 30 - Dec 31
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (447)
9.4/10
Exceptional
(447)
The price is CNY1,184
CNY1,184
CNY1,344 total
includes taxes & fees
Dec 28 - Dec 29
TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (551)
9.2/10
Wonderful
(551)
The price is CNY799
CNY799
CNY906 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1004)
9.0/10
Wonderful
(1004)
The price is CNY770
CNY770
CNY874 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very Good, (755)
8.4/10
Very Good
(755)
The price is CNY1,128
CNY1,128
CNY1,280 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1000)
8.6/10
Excellent
(1000)
The price is CNY736
CNY736
CNY835 total
includes taxes & fees
Jan 2 - Jan 3, 2026
9.8 out of 10, Exceptional, (414)
9.8/10
Exceptional
(414)
TownePlace Suites by Marriott® Jacksonville Mayport
TownePlace Suites by Marriott® Jacksonville Mayport3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (67)
9.8/10
Exceptional
(67)
The price is CNY813
CNY813
CNY922 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Element Jacksonville Beach
Element Jacksonville Beach3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (524)
9.6/10
Exceptional
(524)
The price is CNY1,009
CNY1,009
CNY1,145 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.6 out of 10, Exceptional, (291)
9.6/10
Exceptional
(291)
The price is CNY1,184
CNY1,184
CNY1,344 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Holiday Inn Express & Suites Jacksonville - Town Center by IHG2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1002)
9.6/10
Exceptional
(1002)
The price is CNY918
CNY918
CNY1,042 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.4 out of 10, Exceptional, (813)
9.4/10
Exceptional
(813)
The price is CNY2,795
CNY2,795
CNY3,320 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Lodge and Club at Ponte Vedra Beach
The Lodge and Club at Ponte Vedra Beach5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (688)
9.4/10
Exceptional
(688)
The price is CNY2,795
CNY2,795
CNY3,320 total
includes taxes & fees
Jan 3 - Jan 4, 2026
AC Hotel Jacksonville St Johns Town Center
AC Hotel Jacksonville St Johns Town Center2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (169)
9.4/10
Exceptional
(169)
The price is CNY1,149
CNY1,149
CNY1,304 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Jacksonville Beach/Oceanfront
Hampton Inn Jacksonville Beach/Oceanfront3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2609)
9.2/10
Wonderful
(2609)
The price is CNY925
CNY925
CNY1,050 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Hyatt Place Jacksonville / St. Johns Town Center
Hyatt Place Jacksonville / St. Johns Town Center3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1002)
9.2/10
Wonderful
(1002)
The price is CNY863
CNY863
CNY980 total
includes taxes & fees
Dec 29 - Dec 30
Four Points by Sheraton Jacksonville Beachfront
Four Points by Sheraton Jacksonville Beachfront3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1000)
9.0/10
Wonderful
(1000)
The price is CNY1,247
CNY1,247
CNY1,415 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1004)
9.2/10
Wonderful
(1004)
The price is CNY650
CNY650
CNY738 total
includes taxes & fees
Dec 28 - Dec 29
Margaritaville Jacksonville Beach
Margaritaville Jacksonville Beach2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3435)
9.0/10
Wonderful
(3435)
The price is CNY939
CNY939
CNY1,066 total
includes taxes & fees
Dec 28 - Dec 29
Residence Inn by Marriott Jacksonville South/Bartram Park
Residence Inn by Marriott Jacksonville South/Bartram Park3.0 star property
17.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (620)
9.2/10
Wonderful
(620)
The price is CNY813
CNY813
CNY923 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Other landmarks near Mayo Clinic Florida
Adventure Landing
4.1/5 (157 reviews)
If thrills are what you're after, head to Adventure Landing, located 1 mi (1.7 km) from central Jacksonville Beach. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. If you have fun at Adventure Landing, you'll love Oceanfront Park, located nearby.
Windsor Parke Golf Club
You might want to practice your swing at Windsor Parke Golf Club, a golf course located 12.3 mi (19.8 km) from central Jacksonville. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. If Windsor Parke Golf Club doesn't quite scratch your golfing itch, Jacksonville Beach Golf Club, and Harbor City Municipal Golf Course are also nearby.
Harbor City Municipal Golf Course
You might want to play some rounds at Harbor City Municipal Golf Course, located 14.3 mi (23 km) from central Jacksonville. Why not take a stroll along the beaches and watch the sunset while you're here? If Harbor City Municipal Golf Course doesn't quite scratch your golfing itch, TPC Sawgrass, and Windsor Parke Golf Club are also nearby.
Cradle Creek Preserve
If you like spending time outside, why not spend the afternoon at Cradle Creek Preserve, a park located 15.3 mi (24.7 km) from the center of Jacksonville. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches. Want to stretch your legs some more? Head to Oceanfront Park and Huguenot Park, both nearby.
Jacksonville Beach Golf Club
3.9/5 (58 reviews)
You might want to play some rounds at Jacksonville Beach Golf Club, located 0.5 mi (0.8 km) from central Jacksonville Beach. Hotels.com travelers also say the area is great for couples and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If Jacksonville Beach Golf Club doesn't quite scratch your golfing itch, Windsor Parke Golf Club, and Lagoon Course at Ponte Vedra Inn Club are also nearby.
Frequently asked questions
What are the best hotels near Mayo Clinic Florida?
- Guests love staying at Hilton Jacksonville At Mayo Clinic, which is a hotel near Mayo Clinic Florida.
- Also highly rated is Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches, which is just steps away.
- With 7,481 hotels, vacation rentals, and other accommodations in the area, you'll have plenty to choose from.
How much does it cost to stay in a hotel near Mayo Clinic Florida?
On Hotels.com, you can find a variety of room prices depending on when and where you plan to go. Simply sort by price on the search results and filter by your preferred criteria to find the best options for you and your budget.
- Search for the lowest price per night from CNY738
What cheap hotels are close to Mayo Clinic Florida?
- Quality Inn Atlantic Beach - Mayo Clinic Jax Area is a budget-friendly hotel near Mayo Clinic Florida and offers a free full breakfast, free parking, and free in-room WiFi.
- A second low-cost choice is Wyndham Garden Jacksonville, which is a short drive away.
Can I find hotels close to Mayo Clinic Florida that are fully refundable?
Yes, you'll find many hotels that offer refundable room rates as long as you cancel by the cancellation deadline. Find refundable rates using the "Fully refundable" filter when you search for hotels.
- A couple of highly rated hotels close to Mayo Clinic Florida that offer these rates are Ponte Vedra Inn & Club and The Lodge and Club at Ponte Vedra Beach.
What are the best romantic hotels near Mayo Clinic Florida?
- For a romantic stay, Hilton Jacksonville At Mayo Clinic offers a restaurant, an outdoor pool, and proposal/romance packages. It's steps from Mayo Clinic Florida.
- Residence Inn By Marriott Jacksonville - Mayo Clinic Area is another great choice, and it's just steps away.
What are the best hotels close to Mayo Clinic Florida with free breakfast?
- Begin your day with a free buffet breakfast at Residence Inn By Marriott Jacksonville - Mayo Clinic Area, which is steps from Mayo Clinic Florida.
- Azaleana Manor is also a recommended place to stay with a free continental breakfast, and it's located 30 minutes away by car.
Which hotels near Mayo Clinic Florida have rooms with great views?
- At Hilton Jacksonville At Mayo Clinic, there are rooms where you can take in the water views. The hotel is steps from Mayo Clinic Florida.
- Also recommended is Ponte Vedra Inn & Club, which has rooms with ocean or golf views.
What are the best family hotels close to Mayo Clinic Florida?
- Keep the family happy with a stay at Hilton Jacksonville At Mayo Clinic which offers free cribs, children's meals, and an outdoor pool. Mayo Clinic Florida is just steps away.
- Also consider Ponte Vedra Inn & Club as another great choice for your family's trip.
What are the best luxury hotels near Mayo Clinic Florida?
- Pamper yourself with a stay at Hilton Jacksonville At Mayo Clinic, which is steps from Mayo Clinic Florida. This hotel features a restaurant called Coastal Kitchen, and offers an outdoor pool.
- A second luxurious choice is Ponte Vedra Inn & Club, which is a short drive away.
What are the best hotels near Mayo Clinic Florida with free parking?
- Drive and park with ease when you stay at Hilton Jacksonville At Mayo Clinic, which offers free parking. You'll be steps from Mayo Clinic Florida.
- Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches also has free parking and is just steps away.
What are the best hotels near Mayo Clinic Florida with a pool?
- Travelers can enjoy the outdoor pool at Hilton Jacksonville At Mayo Clinic. Mayo Clinic Florida is steps from the hotel.
- Another great choice for a hotel with a pool is Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches.
What cheap motels can I book close to Mayo Clinic Florida?
- To save on your stay near Mayo Clinic Florida, take a look at Salt Air Inn & Suites, which offers an outdoor pool and a free local cuisine breakfast.
- Studio 6 Jacksonville, FL - Baymeadows is another affordable motel to consider in the area.
What are the best things to see and do around my hotel near Mayo Clinic Florida?
- Before or after your visit to Mayo Clinic Florida, you can check out nearby sights like St. Johns Town Center, TPC Sawgrass, and Jacksonville Beach Pier.
- Other places in the area are Kathryn Abbey Hanna Park, UNF Arena, and The Avenues.
What are the best pet-friendly hotels close to Mayo Clinic Florida?
- Your pet companion can join you at Residence Inn By Marriott Jacksonville - Mayo Clinic Area, which is steps from Mayo Clinic Florida.
- One Ocean Resort and Spa is another pet-friendly option.
Keep exploring
- Palatka Hotels
- Hotels with a Pool in St. Augustine Beach
- Hotels near Methadone Clinic
- Golf Hotels near Aviles Street
- Apartments in Palm Coast
- Luxury Hotels in Sawgrass
- Cottages in American Beach
- Hotels with Free Breakfast in Palatka
- Hotels with Parking near Butler Beach State Park
- Cheap Hotels in Westside
- Hotels near Military Museum of North Florida
- Luxury Hotels near Vilano Beach
- Hotels with a Pool near Vilano Beach
- Motels in Vilano Beach
- Hotels with Parking in Flagler Beach
- Luxury Hotels near Peters Point Beachfront Park
- Hotels near Clay County Fairgrounds
- Cheap Hotels near Vilano Beach
- Sanderson Hotels
- Hotels near South Beach Park and Sunshine Playground
- Family Hotels in Ponte Vedra Beach
- Jacksonville Beach Hotels
- Jacksonville Hotels
- Hotels with Kitchens in Northeast Florida
- Saint Augustine Shores Hotels
- Family Hotels in Palatka
- Lgbtqia Welcoming Hotels in Orange Park
- Cheap Hotels in St. Augustine Beach
- Hotels near Osceola National Forest
- St. Augustine South Hotels
- Family Hotels in Orange Park
- Hotels with a Pool in Palatka
- Hotels near Willow Branch Park
- Pet-Friendly Hotels in Northwest
- Cheap Hotels in Jacksonville Beach
- Hotels near James F. Holland Memorial Park
- Luxury Hotels in Jacksonville
- Hotels with Kitchens near American Beach
- Hotels near Palatka Station
- Cottages in Crescent City
- Hotels near Jacksonville Beach Pier
- Golf Hotels near Timucuan Ecological & Historical Preserve
- Cheap Hotels in Palm Coast
- Business Hotels near Vilano Beach
- Luxury Hotels in St. Augustine Beach
- Family Hotels near Vilano Beach
- St. Augustine Beach Hotels
- Business Hotels near St. George Street
- Sports Complex Hotels
- Luxury Hotels in South Ponte Vedra Beach
- Hotels near Hammock Dunes Links Course
- Yulee Hotels
- Hotels with Free Breakfast in Arlington
- Hotels near AdventHealth Palm Coast
- Apartments in St. George Street
- Hotels with Parking in Orange Park