Hotels in Byron

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Check prices for these dates

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Where to stay in Byron?

Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
7.2 out of 10, Good, (1027)
  • cleanliness
    Convenient location near Mayo Clinic with free daily breakfast and on-site fitness.
The price is CNY504
CNY581 total
includes taxes & fees
Jan 1 - Jan 2, 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Budget hotels in Byron and vicinity

Lobby
Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1003)
The price is CNY381
CNY439 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Super 8 by Wyndham Rochester Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Byron

Putting Green

You might want to play some rounds at Putting Green, located 1.2 mi (1.9 km) from central Byron. If Putting Green doesn't quite scratch your golfing itch, Somerby Golf Club, and Links of Byron Mini Golf are also nearby.
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East Brookfield Park

East Brookfield Park is worth a visit, located 0.7 mi (1.1 km) from central Byron.
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Check out reviews of Byron hotels guests love

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent
"The staff was very friendly and the room spotless. "
Judith 1-night trip
Posted 1 day ago
EVEN Hotel Rochester - Mayo Clinic Area by IHG

Frequently asked questions

How much does a hotel room cost in Byron?
You can find top hotels in Byron from CNY569 with options to suit your budget and needs. To find an affordable hotel in Byron that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at Byron hotels?
Discover great deals on Byron hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Byron hotels.
Can I book Byron hotels with free cancellation?
To book a refundable Byron hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers recommend in Byron?
Guests like Kahler Grand Hotel, Kahler Inn and Suites - Mayo Clinic Area and Hampton Inn Rochester-South.
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.