
Hotels in Byron
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Quality Inn near Medical Center
Quality Inn near Medical Center
2.5 star property
Rochester
7.8 out of 10, Good, (815)
7.8/10
Good
(815)
cleanliness Convenient Mayo Clinic access with free breakfast, parking, and an indoor pool.
The price is CNY410
CNY410
CNY472 total
includes taxes & fees
Jan 9 - Jan 10




Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1002)
8.8/10
Excellent
(1002)
cleanliness Modern rooms near Mayo Clinic with indoor pool and free hot breakfast daily.
The price is CNY510
CNY510
CNY587 total
includes taxes & fees
Jan 11 - Jan 12




Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (897)
8.8/10
Excellent
(897)
cleanliness Relax in quiet comfort with Mayo Clinic just a 15-minute walk away from this hotel.
The price is CNY559
CNY559
CNY644 total
includes taxes & fees
Jan 24 - Jan 25




Sleep Inn & Suites West-Near Medical Center
Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (586)
9.0/10
Wonderful
(586)
cleanliness Convenient hotel near Mayo Clinic with indoor pool and complimentary perks.
The price is CNY566
CNY566
CNY652 total
includes taxes & fees
Jan 9 - Jan 10




America's Stay Inn Stewartville
America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very Good, (419)
8.0/10
Very Good
(419)
cleanliness Explore Mayo Clinic just 15 minutes away from this convenient Stewartville hotel.




Hampton Inn & Suites Rochester-North
Hampton Inn & Suites Rochester-North
2.5 star property
Rochester
9.2 out of 10, Wonderful, (1002)
9.2/10
Wonderful
(1002)
cleanliness Modern Rochester hotel with Mayo Clinic access and revitalizing pool amenities.
The price is CNY625
CNY625
CNY719 total
includes taxes & fees
Jan 11 - Jan 12




La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.2 out of 10, Good, (1032)
7.2/10
Good
(1032)
cleanliness Convenient location near Mayo Clinic with free daily breakfast and on-site fitness.
The price is CNY498
CNY498
CNY573 total
includes taxes & fees
Jan 4 - Jan 5




Baymont by Wyndham Kasson Rochester Area
Baymont by Wyndham Kasson Rochester Area
2.5 star property
Kasson
6.6 out of 10, (373)
6.6/10
(373)
cleanliness Unwind in tranquil Kasson, just a short drive from Rochester's attractions.
The price is CNY451
CNY451
CNY485 total
includes taxes & fees
Jan 11 - Jan 12




Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
2.0 star property
Rochester
8.0 out of 10, Very Good, (1000)
8.0/10
Very Good
(1000)
cleanliness Serene stay near Mayo Clinic with complimentary morning fare and fitness options.
The price is CNY446
CNY446
CNY513 total
includes taxes & fees
Jan 5 - Jan 6




Staybridge Suites Rochester - Commerce Dr NW by IHG
Staybridge Suites Rochester - Commerce Dr NW by IHG
3.0 star property
Rochester
8.8 out of 10, Excellent, (511)
8.8/10
Excellent
(511)
cleanliness Spacious suites with indoor pool just minutes from Mayo Clinic medical campuses.
The price is CNY783
CNY783
CNY901 total
includes taxes & fees
Jan 23 - Jan 24




Spark by Hilton Rochester South
Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (337)
9.2/10
Wonderful
(337)
cleanliness Cozy lodging near Mayo Clinic with complimentary breakfast and indoor pool access.
The price is CNY493
CNY493
CNY567 total
includes taxes & fees
Jan 11 - Jan 12




Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 star property
Kutzky Park
7.8 out of 10, Good, (1006)
7.8/10
Good
(1006)
cleanliness Serene stay near Mayo Clinic with easy access to local dining and shopping options.
The price is CNY524
CNY524
CNY603 total
includes taxes & fees
Jan 4 - Jan 5




AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very Good, (1156)
8.2/10
Very Good
(1156)
cleanliness Peaceful retreat near Mayo Clinic with serene atmosphere and indoor pool.
The price is CNY539
CNY539
CNY620 total
includes taxes & fees
Jan 6 - Jan 7




Econo Lodge Mayo Clinic Area
Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (909)
9.0/10
Wonderful
(909)
cleanliness Restful retreat near Mayo Clinic with 24-hour fitness center and complimentary perks.
The price is CNY472
CNY472
CNY543 total
includes taxes & fees
Jan 9 - Jan 10




Quality Inn & Suites Mayo Clinic Area
Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (836)
8.8/10
Excellent
(836)
cleanliness Quiet refuge in Rochester's medical district with free hot breakfast daily.
The price is CNY462
CNY462
CNY540 total
includes taxes & fees
Jan 31 - Feb 1




Hampton Inn Rochester-South
Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1003)
9.0/10
Wonderful
(1003)
cleanliness Peaceful hotel near Mayo Clinic with indoor pool and daily complimentary breakfast.
The price is CNY569
CNY569
CNY655 total
includes taxes & fees
Jan 24 - Jan 25




Country Inn & Suites by Radisson, Rochester, MN
Country Inn & Suites by Radisson, Rochester, MN
2.5 star property
Rochester
7.6 out of 10, Good, (1001)
7.6/10
Good
(1001)
cleanliness Central hotel near Mayo Clinic offers peaceful rooms and free perks for the weary.
The price is CNY455
CNY455
CNY524 total
includes taxes & fees
Jan 11 - Jan 12




TownePlace Suites by Marriott Rochester
TownePlace Suites by Marriott Rochester
3.0 star property
Rochester
8.8 out of 10, Excellent, (539)
8.8/10
Excellent
(539)
The price is CNY588
CNY588
CNY677 total
includes taxes & fees
Jan 7 - Jan 8




Comfort Inn & Suites West - Medical Center
Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
9.0 out of 10, Wonderful, (531)
9.0/10
Wonderful
(531)
cleanliness Stay minutes from Mayo Clinic with indoor pool and fitness center access.
The price is CNY592
CNY592
CNY682 total
includes taxes & fees
Jan 18 - Jan 19




Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
2.5 star property
Rochester
8.2 out of 10, Very Good, (798)
8.2/10
Very Good
(798)
cleanliness Ideal hotel for Mayo Clinic visitors, with a convenient location and indoor pool.
The price is CNY657
CNY657
CNY757 total
includes taxes & fees
Jan 7 - Jan 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Budget hotels in Byron and vicinity




Super 8 by Wyndham Rochester Mayo Clinic Area
Super 8 by Wyndham Rochester Mayo Clinic Area2.0 star property
Rochester
7.8 out of 10, Good, (1001)
7.8/10
Good
(1001)
The price is CNY380
CNY380
CNY438 total
includes taxes & fees
Jan 15 - Jan 16




MainStay Suites Rochester South Mayo Clinic
MainStay Suites Rochester South Mayo Clinic2.5 star property
Rochester
7.0 out of 10, Good, (94)
7.0/10
Good
(94)
The price is CNY409
CNY409
CNY471 total
includes taxes & fees
Jan 18 - Jan 19




7.8 out of 10, Good, (815)
7.8/10
Good
(815)
The price is CNY410
CNY410
CNY472 total
includes taxes & fees
Jan 9 - Jan 10




7.6 out of 10, Good, (534)
7.6/10
Good
(534)




Baymont by Wyndham Rochester Mayo Clinic Area
Baymont by Wyndham Rochester Mayo Clinic Area2.5 star property
Rochester
7.2 out of 10, Good, (724)
7.2/10
Good
(724)
The price is CNY416
CNY416
CNY479 total
includes taxes & fees
Jan 11 - Jan 12




Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic2.0 star property
Rochester
8.0 out of 10, Very Good, (1000)
8.0/10
Very Good
(1000)
The price is CNY446
CNY446
CNY513 total
includes taxes & fees
Jan 5 - Jan 6




Country Inn & Suites by Radisson, Rochester, MN
Country Inn & Suites by Radisson, Rochester, MN2.5 star property
Rochester
7.6 out of 10, Good, (1001)
7.6/10
Good
(1001)
The price is CNY455
CNY455
CNY524 total
includes taxes & fees
Jan 11 - Jan 12




Extended Stay America Suites Rochester North
Extended Stay America Suites Rochester North2.5 star property
Rochester
7.6 out of 10, Good, (683)
7.6/10
Good
(683)
The price is CNY440
CNY440
CNY507 total
includes taxes & fees
Jan 4 - Jan 5




8.0 out of 10, Very Good, (419)
8.0/10
Very Good
(419)




9.0 out of 10, Wonderful, (909)
9.0/10
Wonderful
(909)
The price is CNY472
CNY472
CNY543 total
includes taxes & fees
Jan 9 - Jan 10




Quality Inn & Suites Mayo Clinic Area
Quality Inn & Suites Mayo Clinic Area2.5 star property
Rochester
8.8 out of 10, Excellent, (836)
8.8/10
Excellent
(836)
The price is CNY462
CNY462
CNY540 total
includes taxes & fees
Jan 31 - Feb 1




La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S3.0 star property
Rochester
7.2 out of 10, Good, (1032)
7.2/10
Good
(1032)
The price is CNY498
CNY498
CNY573 total
includes taxes & fees
Jan 4 - Jan 5




9.2 out of 10, Wonderful, (337)
9.2/10
Wonderful
(337)
The price is CNY493
CNY493
CNY567 total
includes taxes & fees
Jan 11 - Jan 12




Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHG2.5 star property
Rochester
8.8 out of 10, Excellent, (1002)
8.8/10
Excellent
(1002)
The price is CNY510
CNY510
CNY587 total
includes taxes & fees
Jan 11 - Jan 12




Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area2.5 star property
Kutzky Park
7.8 out of 10, Good, (1006)
7.8/10
Good
(1006)
The price is CNY524
CNY524
CNY603 total
includes taxes & fees
Jan 4 - Jan 5




AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic3.0 star property
Rochester
8.2 out of 10, Very Good, (1156)
8.2/10
Very Good
(1156)
The price is CNY539
CNY539
CNY620 total
includes taxes & fees
Jan 6 - Jan 7




8.8 out of 10, Excellent, (1002)
8.8/10
Excellent
(1002)




Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (897)
8.8/10
Excellent
(897)
The price is CNY559
CNY559
CNY644 total
includes taxes & fees
Jan 24 - Jan 25




9.0 out of 10, Wonderful, (1003)
9.0/10
Wonderful
(1003)
The price is CNY569
CNY569
CNY655 total
includes taxes & fees
Jan 24 - Jan 25




Sleep Inn & Suites West-Near Medical Center
Sleep Inn & Suites West-Near Medical Center2.5 star property
Rochester
9.0 out of 10, Wonderful, (586)
9.0/10
Wonderful
(586)
The price is CNY566
CNY566
CNY652 total
includes taxes & fees
Jan 9 - Jan 10
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Byron
Pet friendly
Family friendly
Top landmarks in Byron
Check out reviews of Byron hotels guests love

Kahler Grand Hotel
10/10 Excellent
"Clean, comfortable room. The staff was very helpful"

Hotel Indigo Rochester – Mayo Clinic Area by IHG
10/10 Excellent
"The hotel was clean and a friendly staff at check in. We love that the hotel skyway is connected to Mayo, so could walk to appts. inside on a cold day. We also appreciated a noon check out."

Brentwood Inn & Suites
10/10 Excellent
"LOVE this hotel. We stay every time we go to Mayo. It is out dated but SUPER CLEAN, a place you can tell employees take pride in. We always recognize staff even through the years. Everyone is always helpful and kind. Great breakfast as well. One huge perk too is it has access in the hotel to the subway system. Thanks Brentwood for another awesome stay, you never disappoint. "

The Berkman
10/10 Excellent
"It was a bit tricky finding our area we could park in but it worked out. "

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
10/10 Excellent
"Friendly staff and very clean "

EVEN Hotel Rochester - Mayo Clinic Area by IHG
10/10 Excellent
"The staff was very friendly and the room spotless. "

Kahler Inn and Suites - Mayo Clinic Area
10/10 Excellent
"Great service. Clean room. Good breakfast"

Hyatt House Rochester/Mayo Clinic Area
10/10 Excellent
"Clean room. Appreciate the shuttle service "

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
10/10 Excellent
"It was great location- clean friendly convenience, good breakfast
"
Frequently asked questions
How much does a hotel room cost in Byron?
You can find top hotels in Byron from CNY540 with options to suit your budget and needs. To find an affordable hotel in Byron that meets all of your requirements, just apply filters on Hotels.com and sort hotels by "Price: low to high".
How can I find deals and earn rewards at Byron hotels?
Discover great deals on Byron hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. And make sure to check out our last-minute deals on Byron hotels.
Can I book Byron hotels with free cancellation?
To book a refundable Byron hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers recommend in Byron?
Can I book refundable accommodations in Byron?
If you're looking for the flexibility to change your plans to Byron, most properties provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Byron be like during my vacation?
July and August are typically the warmest months in Byron when the average temp is 67°F. January and February are the coldest months when the average temperature is 21°F. June and May are the months with the most rain.
Why should I book my Byron hotel with Hotels.com?
There are lots of reasons to book your Byron trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
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