Hotels in Santa Clara
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Mahogany Suites
Mahogany Suites
2.0 star property
Rousseau
10.0 out of 10, Exceptional, (1)
10/10
Exceptional
(1)
The price is CNY824
CNY824
CNY906 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Gamboa Rainforest Reserve
Gamboa Rainforest Reserve
3.5 star property
Colon
7.8 out of 10, Good, (666)
7.8/10
Good
(666)
The price is CNY1,172
CNY1,172
CNY1,290 total
includes taxes & fees
Jan 4 - Jan 5, 2026
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Modal
2.0 star property
Panama City
La Concordia Boutique Hotel
La Concordia Boutique Hotel
4.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (194)
9.6/10
Exceptional
(194)
The price is CNY2,333
CNY2,333
CNY2,566 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Amarla Boutique Hotel Casco Viejo
Amarla Boutique Hotel Casco Viejo
3.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (106)
9.6/10
Exceptional
(106)
Oasis Hotel
Oasis Hotel
3.0 star property
Casco Viejo
8.4 out of 10, Very Good, (106)
8.4/10
Very Good
(106)
The price is CNY523
CNY523
CNY575 total
includes taxes & fees
Dec 23 - Dec 24
Summit Rainforest & Golf Resort
Summit Rainforest & Golf Resort
4.0 star property
Panama City
8.4 out of 10, Very Good, (1001)
8.4/10
Very Good
(1001)
The price is CNY502
CNY502
CNY553 total
includes taxes & fees
Dec 28 - Dec 29
Hotel La Compañía Casco Antiguo
Hotel La Compañía Casco Antiguo
4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
9.8/10
Exceptional
(258)
The price is CNY2,268
CNY2,268
CNY2,495 total
includes taxes & fees
Dec 24 - Dec 25
Central Hotel Panama Casco Viejo
Central Hotel Panama Casco Viejo
4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1007)
9.0/10
Wonderful
(1007)
The price is CNY1,457
CNY1,457
CNY1,603 total
includes taxes & fees
Dec 23 - Dec 24
Sofitel Legend Casco Viejo, Panama City
Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (560)
9.8/10
Exceptional
(560)
The price is CNY2,630
CNY2,630
CNY2,893 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Hotel Plaza Herrera
Hotel Plaza Herrera
4.0 star property
Casco Viejo
10.0 out of 10, Exceptional, (13)
10/10
Exceptional
(13)
The price is CNY2,016
CNY2,016
CNY2,218 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Hyatt Regency Panama City
Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (126)
10/10
Exceptional
(126)
The price is CNY1,056
CNY1,056
CNY1,162 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Panama Canal by IHG
Holiday Inn Panama Canal by IHG
3.5 star property
Panama City
8.6 out of 10, Excellent, (443)
8.6/10
Excellent
(443)
The price is CNY682
CNY682
CNY867 total
includes taxes & fees
Dec 21 - Dec 22
La Cuadra by Wynwood House
La Cuadra by Wynwood House
3.5 star property
El Chorrillo
9.2 out of 10, Wonderful, (44)
9.2/10
Wonderful
(44)
The price is CNY779
CNY779
CNY1,033 total
includes taxes & fees
Dec 21 - Dec 22
Dovle Residences by HMS-Preferred Member
Dovle Residences by HMS-Preferred Member
3.0 star property
San Francisco
The price is CNY1,362
CNY1,362
CNY1,499 total
includes taxes & fees
Dec 27 - Dec 28
InterContinental Miramar Panama by IHG
InterContinental Miramar Panama by IHG
4.0 star property
Bella Vista
8.6 out of 10, Excellent, (535)
8.6/10
Excellent
(535)
The price is CNY1,225
CNY1,225
CNY1,348 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
8.8/10
Excellent
(1001)
The price is CNY1,120
CNY1,120
CNY1,231 total
includes taxes & fees
Jan 3 - Jan 4, 2026
The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1001)
8.0/10
Very Good
(1001)
The price is CNY1,605
CNY1,605
CNY1,765 total
includes taxes & fees
Jan 8 - Jan 9, 2026
American Trade Hotel
American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (607)
9.4/10
Exceptional
(607)
The price is CNY2,053
CNY2,053
CNY2,259 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Gran Evenia Panama
Gran Evenia Panama
4.5 star property
Bella Vista
9.2 out of 10, Wonderful, (195)
9.2/10
Wonderful
(195)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santa Clara
Apart hotel
Apartment
Ocean view
Family friendly
Pet friendly
Learn more about Santa Clara
The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.
Check out reviews of Santa Clara hotels guests love
Hotel Riu Plaza Panama
10/10 Excellent
"The Riu EXCEEDED all my expectations. The customer service is definitely a 10, the breakfast is definitely a 10!! I met the kindest server Katuschka…I loved her. She would come hope to be back soon. "
Megapolis Hotel Panamá
10/10 Excellent
"Clean room, comfortable, spacious. The breakfast was really good! "
Plaza Paitilla Inn Hotel
10/10 Excellent
"The staff were friendly and helpful. Check in was smooth, room was clean and had a nice view of the bay. The included breakfast buffet was great with a wide selection of foods. I would definitely recommend this hotel."
Waldorf Astoria Panama
10/10 Excellent
"Amazing breakfast the 1st day, ok breakfast the 2nd day. Concierge was amazing. Loved the hotel and it's smell. Absolutely recommend! Teenage kids loved it too!"
Decapolis Hotel Panama City
10/10 Excellent
"Nice and clean room. "
Marriott Panama Hotel
10/10 Excellent
"Great hotel and staff!"
The Westin Playa Bonita Panama
10/10 Excellent
"Excellent good service good people good everything love it"
Las Americas Golden Tower Panama
10/10 Excellent
"It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was cheap. Uber to PTY airport was $17. Views from the hotel are beautiful. Pool was the best, clean, lots of lights, cozy and just what we needed to swim after long day of sightseing Panama canal, boat tour to Monkey Islands, long walk along Cinta Costera and dinner with friends on the 5th floor of Golden tower."
Dreams Playa Bonita Panama - All Inclusive
10/10 Excellent
"Excellent service, good even more so. The property is clean, however the chairs and curtains show their age in a major way.
Staff are friendly and every interaction was pleasant. We would definitely return to this resort. "
Frequently asked questions
How much does a hotel room cost in Santa Clara?
You can choose a great hotel in Santa Clara from CNY395 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Santa Clara that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.
How can I find deals and earn rewards at Santa Clara hotels?
Discover great deals on Santa Clara hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Santa Clara hotels.
Can I book Santa Clara hotels with free cancellation?
To book a refundable Santa Clara hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some popular hotels in central Santa Clara?
If you're looking for hotels in central Santa Clara, check out Gatun Lake Lodge Hotel. Travelers love Gatun Lake Lodge Hotel for its location, as well as the outdoor pool, poolside bar and free continental breakfast this lodge offers.
Can I book a refundable accommodation in Santa Clara?
If you want the flexibility to change your plans to Santa Clara, most properties offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Clara be like during my trip?
With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.
Why should I book my Santa Clara accommodation with Hotels.com?
There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.