Hotels in Santa Clara
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Gamboa Rainforest Reserve
Gamboa Rainforest Reserve
3.5 star property
Colon
7.8 out of 10, Good, (666)
7.8/10
Good
(666)
The price is CNY1,172
CNY1,172
CNY1,290 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Summit Rainforest & Golf Resort
Summit Rainforest & Golf Resort
4.0 star property
Panama City
8.4 out of 10, Very Good, (1002)
8.4/10
Very Good
(1002)
The price is CNY508
CNY508
CNY559 total
includes taxes & fees
Dec 23 - Dec 24
Hotel Riu Plaza Panama
Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4701)
9.0/10
Wonderful
(4701)
The price is CNY770
CNY770
CNY847 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Radisson Hotel Panama Canal
Radisson Hotel Panama Canal
4.5 star property
Amador
8.4 out of 10, Very Good, (1004)
8.4/10
Very Good
(1004)
The price is CNY587
CNY587
CNY645 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hyatt Regency Panama City
Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (127)
10/10
Exceptional
(127)
The price is CNY1,104
CNY1,104
CNY1,214 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Mahogany Suites
Mahogany Suites
2.0 star property
Rousseau
9.0 out of 10, Wonderful, (2)
9.0/10
Wonderful
(2)
The price is CNY824
CNY824
CNY906 total
includes taxes & fees
Dec 28 - Dec 29
Ramada Plaza by Wyndham Panama Punta Pacifica
Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1120)
9.6/10
Exceptional
(1120)
The price is CNY689
CNY689
CNY758 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Marriott Panama Hotel
Marriott Panama Hotel
4.0 star property
Panama City
9.0 out of 10, Wonderful, (1007)
9.0/10
Wonderful
(1007)
The price is CNY1,051
CNY1,051
CNY1,156 total
includes taxes & fees
Jan 2 - Jan 3, 2026
The Westin Playa Bonita Panama
The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1003)
8.0/10
Very Good
(1003)
The price is CNY1,605
CNY1,605
CNY1,765 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Albrook Inn
Albrook Inn
3.0 star property
Panama City
7.8 out of 10, Good, (561)
7.8/10
Good
(561)
The price is CNY461
CNY461
CNY507 total
includes taxes & fees
Dec 23 - Dec 24
Hotel Milan
Hotel Milan
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (429)
9.0/10
Wonderful
(429)
The price is CNY282
CNY282
CNY310 total
includes taxes & fees
Dec 23 - Dec 24
Holiday Inn Panama Canal by IHG
Holiday Inn Panama Canal by IHG
3.5 star property
Panama City
8.6 out of 10, Excellent, (443)
8.6/10
Excellent
(443)
The price is CNY690
CNY690
CNY759 total
includes taxes & fees
Jan 2 - Jan 3, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (642)
9.6/10
Exceptional
(642)
The price is CNY1,579
CNY1,579
CNY1,737 total
includes taxes & fees
Jan 17 - Jan 18, 2026
The Executive Hotel
The Executive Hotel
3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1004)
9.2/10
Wonderful
(1004)
Riande Urban Hotel
Riande Urban Hotel
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (1055)
8.8/10
Excellent
(1055)
The price is CNY592
CNY592
CNY651 total
includes taxes & fees
Dec 23 - Dec 24
Principe Hotel and Suites
Principe Hotel and Suites
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1610)
9.0/10
Wonderful
(1610)
The price is CNY389
CNY389
CNY428 total
includes taxes & fees
Dec 23 - Dec 24
The Beach House
The Beach House
3.0 star property
Amador
8.4 out of 10, Very Good, (407)
8.4/10
Very Good
(407)
Renaissance Panama City Hotel
Renaissance Panama City Hotel
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (96)
8.8/10
Excellent
(96)
The price is CNY817
CNY817
CNY898 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2137)
9.4/10
Exceptional
(2137)
The price is CNY760
CNY760
CNY836 total
includes taxes & fees
Dec 28 - Dec 29
Sheraton Grand Panama
Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (994)
8.6/10
Excellent
(994)
The price is CNY892
CNY892
CNY981 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santa Clara
Apartment
Ocean view
Family friendly
Pet friendly
Learn more about Santa Clara
The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.
Check out reviews of Santa Clara hotels guests love
Plaza Paitilla Inn Hotel
10/10 Excellent
"I had a wonderful stay at this hotel and highly recommend it.
The location is excellent and very central, very close to the Jewish community, including a synagogue and Chabad.
Everything is within walking distance — a pleasant neighborhood with a park, supermarket, pharmacy, and a shopping mall.
The rooms were very clean and well maintained, with a lovely view.
The breakfast was full and generous, with a wide variety of options — nothing was missing.
The internet connection was strong and reliable.
The service was available 24/7, and the staff was helpful and professional.
I would definitely stay here again.
"
Principe Hotel and Suites
10/10 Excellent
"Clean rooms, courteous staff. The front desk team is awesome. 2nd time visiting, i'll definitely be back!"
Hotel Riu Plaza Panama
10/10 Excellent
"The Riu EXCEEDED all my expectations. The customer service is definitely a 10, the breakfast is definitely a 10!! I met the kindest server Katuschka…I loved her. She would come hope to be back soon. "
W Panama
10/10 Excellent
"Excellent stay at the W Panama. Breakfast was great, room service was consistently good, and the pool area was relaxing and well maintained. The on-site shops and restaurants were convenient and high quality. Overall, a very enjoyable experience and I would definitely stay here again."
Megapolis Hotel Panamá
10/10 Excellent
"Clean room, comfortable, spacious. The breakfast was really good! "
The Executive Hotel
10/10 Excellent
"S"
JW Marriott Panama
10/10 Excellent
"Just wonderful hotel"
Waldorf Astoria Panama
10/10 Excellent
"Amazing breakfast the 1st day, ok breakfast the 2nd day. Concierge was amazing. Loved the hotel and it's smell. Absolutely recommend! Teenage kids loved it too!"
Decapolis Hotel Panama City
10/10 Excellent
"Nice and clean room. "
Frequently asked questions
How much does a hotel room cost in Santa Clara?
You can choose a great hotel in Santa Clara from CNY428 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Santa Clara that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.
How can I find deals and earn rewards at Santa Clara hotels?
Discover great deals on Santa Clara hotel stays with Hotels.com. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If it's a spontaneous trip, check out our last-minute deals on Santa Clara hotels.
Can I book Santa Clara hotels with free cancellation?
To book a refundable Santa Clara hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some popular hotels in central Santa Clara?
If you're looking for hotels in central Santa Clara, check out Gatun Lake Lodge Hotel. Travelers love Gatun Lake Lodge Hotel for its location, as well as the outdoor pool, poolside bar and free continental breakfast this lodge offers.
Can I book a refundable accommodation in Santa Clara?
If you want the flexibility to change your plans to Santa Clara, most properties offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Clara be like during my trip?
With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.
Why should I book my Santa Clara accommodation with Hotels.com?
There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.