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Hotels in Santa Ana
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Where to stay in Santa Ana?
7.6 out of 10, Good, (55)
7.6/10
Good
(55)
The price is CNY178
CNY178
CNY196 total
includes taxes & fees
Jan 2 - Jan 3, 2026
6.6 out of 10, (182)
6.6/10
(182)
7.2 out of 10, Good, (15)
7.2/10
Good
(15)
The price is CNY379
CNY379
CNY610 total
includes taxes & fees
Dec 26 - Dec 27
6.0 out of 10, (11)
6.0/10
(11)
9.2 out of 10, Wonderful, (56)
9.2/10
Wonderful
(56)
Room-sofa Bed Stay Rooftop Pool & Gym, A
Room-sofa Bed Stay Rooftop Pool & Gym, A2.0 star property
Santa Ana
2.0 out of 10, (1)
2.0/10
(1)
The price is CNY1,028
CNY1,028
CNY1,130 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Central Hotel Panama Casco Viejo
Central Hotel Panama Casco Viejo4.0 star property
San Felipe, 0.9 km from Santa Ana
9.2 out of 10, Wonderful, (1003)
9.2/10
Wonderful
(1003)
The price is CNY2,505
CNY2,505
CNY2,755 total
includes taxes & fees
Jan 2 - Jan 3, 2026
8.4 out of 10, Very Good, (108)
8.4/10
Very Good
(108)
The price is CNY521
CNY521
CNY573 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Radisson Hotel Panama Canal
Radisson Hotel Panama Canal4.5 star property
Amador, 2.3 km from Santa Ana
8.4 out of 10, Very Good, (1004)
8.4/10
Very Good
(1004)
The price is CNY574
CNY574
CNY631 total
includes taxes & fees
Jan 7 - Jan 8, 2026
8.8 out of 10, Excellent, (417)
8.8/10
Excellent
(417)
The price is CNY335
CNY335
CNY369 total
includes taxes & fees
Dec 28 - Dec 29
7.4 out of 10, Good, (591)
7.4/10
Good
(591)
The price is CNY516
CNY516
CNY567 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Amarla Boutique Hotel Casco Viejo
Amarla Boutique Hotel Casco Viejo3.0 star property
San Felipe, 0.9 km from Santa Ana
9.6 out of 10, Exceptional, (106)
9.6/10
Exceptional
(106)
Hyatt Regency Panama City
Hyatt Regency Panama City4.5 star property
Campo Alegre, 3.3 km from Santa Ana
10.0 out of 10, Exceptional, (131)
10/10
Exceptional
(131)
The price is CNY1,100
CNY1,100
CNY1,210 total
includes taxes & fees
Jan 11 - Jan 12, 2026
9.0 out of 10, Wonderful, (4709)
9.0/10
Wonderful
(4709)
The price is CNY859
CNY859
CNY945 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Plaza Paitilla Inn Hotel
Plaza Paitilla Inn Hotel3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2136)
9.4/10
Exceptional
(2136)
The price is CNY757
CNY757
CNY833 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Hotel La Compañía Casco Antiguo
Hotel La Compañía Casco Antiguo4.5 star property
San Felipe, 0.7 km from Santa Ana
9.8 out of 10, Exceptional, (258)
9.8/10
Exceptional
(258)
The price is CNY2,480
CNY2,480
CNY2,728 total
includes taxes & fees
Jan 5 - Jan 6, 2026
8.8 out of 10, Excellent, (1054)
8.8/10
Excellent
(1054)
The price is CNY590
CNY590
CNY649 total
includes taxes & fees
Jan 8 - Jan 9, 2026
8.8 out of 10, Excellent, (275)
8.8/10
Excellent
(275)
Hotel Faranda Express Soloy and Casino, a member of Radisson Individuals
Hotel Faranda Express Soloy and Casino, a member of Radisson Individuals3.5 star property
Calidonia, 1.4 km from Santa Ana
7.4 out of 10, Good, (148)
7.4/10
Good
(148)
The price is CNY379
CNY379
CNY417 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
When is the best time to visit Santa Ana?
When is the best time to visit Santa Ana?Our prices for hotels in Santa Ana are cheapest in April
When is the best time to visit Santa Ana?
When is the best time to visit Santa Ana?
Our prices for hotels in Santa Ana are cheapest in April
Price trends for hotels in Santa Ana
Pricing is based on two traveler single night rates
Currently viewing crowd sizes and weather for December.
Typical weather for Panama City
December
High crowds
High 29°C / low 24°C. Cloudy most days.
View properties in December 29°
December, High crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Cloudy most days.
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30°
January, Moderate crowds, average high temperature 30 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
30°
February, High crowds, average high temperature 30 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
31°
March, High crowds, average high temperature 31 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
31°
April, Low crowds, average high temperature 31 degrees Celsius, average low temperature 24 degrees Celsius. Sunny most days.
24°
30°
May, Low crowds, average high temperature 30 degrees Celsius, average low temperature 25 degrees Celsius. Rainy most days.
25°
29°
June, Low crowds, average high temperature 29 degrees Celsius, average low temperature 25 degrees Celsius. Rainy most days.
25°
29°
July, High crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
August, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
September, Low crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
October, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
29°
November, Moderate crowds, average high temperature 29 degrees Celsius, average low temperature 24 degrees Celsius. Rainy most days.
24°
Monthly weather averages (˚C)
Check out reviews of Santa Ana hotels guests love
Novotel Panama City
10/10 Excellent
"The hotel was very nice and the staff was great."
Hotel Riu Plaza Panama
10/10 Excellent
"Clean room, friendly and attentive staff, and amenities"
Decapolis Hotel Panama City
10/10 Excellent
"Good"
Megapolis Hotel Panamá
10/10 Excellent
"Best hotel I ever stayed"
Plaza Paitilla Inn Hotel
10/10 Excellent
"I had a wonderful stay at this hotel and highly recommend it.
The location is excellent and very central, very close to the Jewish community, including a synagogue and Chabad.
Everything is within walking distance — a pleasant neighborhood with a park, supermarket, pharmacy, and a shopping mall.
The rooms were very clean and well maintained, with a lovely view.
The breakfast was full and generous, with a wide variety of options — nothing was missing.
The internet connection was strong and reliable.
The service was available 24/7, and the staff was helpful and professional.
I would definitely stay here again.
"
Dreams Playa Bonita Panama - All Inclusive
10/10 Excellent
"Beautiful and luxurious "
Principe Hotel and Suites
10/10 Excellent
"Clean rooms, courteous staff. The front desk team is awesome. 2nd time visiting, i'll definitely be back!"
Marriott Panama Hotel
10/10 Excellent
"Yes"
Casco View Apartments
10/10 Excellent
"We live this property and stay here whenever we are in town."
Frequently asked questions
Is Santa Ana expensive to stay in?
You can find great hotels from CNY196 in Santa Ana to suit a range of budgets. If you're looking for an affordable stay in Santa Ana, Hostal La Cigarra is a great low-cost option. To find the best low-cost hotel on Hotels.com that meets your needs, apply your search filters and then sort hotels by "Price: low to high".
How can I find discounted rates and deals for Santa Ana hotels?
Discover great deals on hotels in Santa Ana with Hotels.com. Sign up for free to unlock member only prices and start earning rewards. It's also a good idea to look at hotel prices mid-week or during the low season as you're likely to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Santa Ana hotels.
Can I receive a refund if I cancel my Santa Ana hotel booking?
The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel your booking. Some Santa Ana hotels require you to cancel more than 24 hours before check-in, so look at your booking beforehand. For extra peace of mind before you book, filter hotels by "Property cancellation options" and select "Fully refundable property".
Is it worth staying in Santa Ana?
You're spoilt for choice with 112 hotels in the area so it's easy to find your perfect somewhere. Basing yourself in Santa Ana makes it easy to explore Panama City, including the neighborhoods of Casco Viejo and Bella Vista.
Find out more about Santa Ana
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