Hotels in New Madrid

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Dec 19 - Dec 20
Tomorrow
Dec 20 - Dec 21
This weekend
Dec 19 - Dec 21
Next weekend
Dec 26 - Dec 28

Where to stay in New Madrid?

Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
8.6 out of 10, Excellent, (443)
The price is CNY655
CNY741 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See more propertiesforward arrow

Top landmarks in New Madrid

New Madrid Historical Museum

4.1/5 (17 reviews)
The center of New Madrid is home to cultural attractions like New Madrid Historical Museum, so you might want to stop by during your stay. If you want to experience more of the culture New Madrid has to offer, head to River Ridge Winery and Hunter-Dawson State Historic Site.
See properties

River Ridge Winery

3.9/5 (10 reviews)
Travelers might want a tour of River Ridge Winery, just one of the places to visit, and located 0.6 mi (1 km) from central New Madrid.
See properties

Learn more about New Madrid

New Madrid is applauded for its cultural attractions such as New Madrid Historical Museum and Hunter-Dawson State Historic Site.

See all hotels in New Madrid
Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

Check out reviews of New Madrid hotels guests love

New Orleans Inn Portageville

New Orleans Inn Portageville

10/10 Excellent
"Yes"
Rachel 2-night trip
Posted 9 days ago
New Orleans Inn Portageville

Frequently asked questions

How much does a hotel room cost in New Madrid?
You can find top hotels in New Madrid from CNY346 with options to suit your budget and needs. If you're looking for an affordable hotel in New Madrid that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.
How can I find deals and earn rewards at New Madrid hotels?
Discover great deals on New Madrid hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on New Madrid hotels.
Can I book New Madrid hotels with free cancellation?
It's easy to book a refundable New Madrid hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What hotels do travelers like in New Madrid?
Guests like Super 8 By Wyndham Marston and Travel Inn.
Can I book refundable accommodations in New Madrid?
If you need the flexibility to change your travel plans to New Madrid, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in New Madrid be like during my vacation?
The warmest months in New Madrid are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 42°F. The rainiest months are March and April.
Why should I book my New Madrid hotel through Hotels.com?
There are plenty of reasons to book your New Madrid travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.