Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in South San Francisco
Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants.
Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.
Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems.
Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.
The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries.
Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.
Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun.
Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.
Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for.
Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.
South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has many other landmarks you might want to see such as Golden Gate Bridge and Alcatraz Island.
See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco and Coastside Comics, both located nearby.
Enjoy the beautiful sunsets and explore San Bruno Point Park, a lovely green space in South San Francisco. Amble around this vibrant area's seaside or experience its acclaimed art scene.
Enjoy an outing to K1 Speed San Francisco during your stay in South San Francisco. Amble around this vibrant area's beautiful beaches and enjoy its top-notch restaurants.
After visiting Centennial Dog Park, make a plan to see the other sights and activities in South San Francisco. Check out the shops and top-notch restaurants in this family-friendly area.
Explore the iconic 'South San Francisco The Industrial City' sign atop Sign Hill Park. Sample diverse cuisines along Grand Avenue or catch breathtaking Bay views from nearby San Bruno Mountain.
Check out reviews of South San Francisco hotels guests love
Chancellor Hotel on Union Square
10/10 Excellent
"Room was clean and quiet. Loved the nice touches with a portable fan, soaps, hair dryer, and more. The first night was rough as the room was very warm. The high was only 70 degrees, so I was surpised that the room stayed uncomfortably warm overnight. My room was on the backside and the sun shined in. Windows only open about 8 inches. The next few nights seemed a little better. I felt competely safe in this area. "
"Nice spacious room, more like a suite than a basic room Room has everything you need. Staff really helpful, friendly and informative. Good location as easy to get buses and trams close by. Lots of places around to eat and drink. Hotel very clean and breakfast nice."
"Loved staying at Hotel Caza! While it wasn’t centrally located for what I wanted to do (most things I wanted to do required a 15-60 minute public transit ride to get to) it was perfectly located for access to Fishermen’s Wharf and Ghirardelli Square, and just generally a nice area to stay.
I had no problem accessing transit from the hotel - bus stop right outside, a couple minutes walk to 2 cable car turnarounds & right around the corner from the F line trolley. Easy slightly uphill straight-shot walk to get to Little Italy and Chinatown up Columbus street.
Almost everything I have to say is a pro - easy check in with a friendly staff, clean room, a person onsite if you want to coordinate/book excursions (a feature I didn’t use but was nice to know was available). I read some reviews that said there were no fridges, but when I got to my room there was a mini fridge so I’m not sure if that was a perk of being an “Expedia VIP” or something the hotel just does now that it didn’t before. The area felt super safe and it was nice the hotel required a room key to get in after dark. The only hotel-con I have is when I turned the shower on the water appeared to be slightly brown. This went away after running it for a minute, and I assume just a product of old pipes. If you’re a light sleeper you might be bothered by the occasional loud bass car driving by, but it was infrequent (not hotel’s fault). Everything else was great, and definitely plan to stay here next time I come to SF. "
"They let me check in early after waiting up all night for my son's plane to land and then upgraded our room upon request with no problem at all. Will definitely stay here again. "
"Jättefint hotell med kanonbra läge nära Fishermans Wharf och flertalet restauranger.
Stora rum med bekväma sängar.
Rent och snyggt. En fantastisk frukostbuffé!
Parkering på 60 dollar/dygn är dock absurt dyrt.
"
"Our stay at the Handlery Union Station was great. It's walkable to various destinations. Also, an easy location to request rideshare. The room was clean, with the pirmary necessities to make your stay comfortable. I'd stay here again. "
Can I book refundable accommodations in South San Francisco?
If you need the flexibility to change your travel plans to South San Francisco, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in South San Francisco if I want a vacation rental instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 32 vacation homes. In addition, you can choose from 10 apartments.
What will the weather in South San Francisco be like during my visit?
The warmest months in South San Francisco are usually September and August with an average temp of 62°F. February and January are the chilliest months when the average temp is 53°F. The rainiest months are December and January.
Why should I book my South San Francisco accommodation with Hotels.com?
There are lots of reasons to book your South San Francisco trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.
Find out more about South San Francisco
Find out more about South San Francisco
South San Francisco is a family-friendly place known for its restaurants. Simply book a local tour to enjoy your stay a little more. Top places to visit include San Francisco Bay. Popular sights in the surrounding area include Chase Center and Oracle Park.
